Klotho? sounds great!
and a lot more on Klotho from a friend of mine:
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On Wed, Feb 11, 2015 at 11:47 AM, John M. “Johnny” Adams, GRG Exec Director wrote:
Dear GRG Member,
A few highlights of Steve Charlap’s post
Protein linked to longevity and enhanced cognition protects against Alzheimer’s symptoms
– Scientists report that raising levels of the life-extending protein klotho can protect against learning and memory deficits in a mouse model of Alzheimer’s disease.
– Remarkably, this boost in cognition occurred despite the accumulation of Alzheimer-related toxins in the brain, such as amyloid-beta and tau
– This was done in a mouse model of Alzheimer’s disease that produced higher levels of this protein throughout the body.
– Cognition was improved in a diseased brain despite it’s riddled with toxins
– Klotho’s benefits may be due to its effect on a the NMDA neurotransmitter receptor in the brain that is crucially involved in learning and memory.
– The next step will be to identify and test drugs that can elevate klotho or mimic its effects on the brain
– There are strong similarities we found between klotho’s effects in humans and mice
– They think this provides good support for pursuing klotho as a potential drug target to treat cognitive disorders in humans, including Alzheimer’s disease
John M. “Johnny” Adams
Executive Director Gerontology Research Group
(949) 922-9786 cell
CEO / Exec. Director
Carl I. Bourhenne Medical Research Foundation / Aging Intervention Foundation