Re: [GRG] Cellular Senescence: senolysis

Dear Walt,

There is some information on blood and plasma experiments here:

Alkast is doing a small 18 person test using transfusions on AL patients to see if there is any improvement too. SENS is also looking at Parabiosis and circulating blood factors too as are Amy Wagers, Conboy etc… My concern about the Alkast study is they have focused on AL rather than say heart disease which would be more preference as improvement in tissue/health would be easily quantifiable and less subjective compared to cognitive ability assesements to measure improvements. 

There were some comparison figures for factors in young vs old blood somewhere but I have not managed to locate them again. It is clear that restoring a younger blood phenotype restores tissues in animal studies and I suspect similar would occur in the human body too. GDF-11 was certainly one factor but alone I do not think its effects will be so profound. 

A proposal for a similar dialysis type intervention using blood factors was proposed recently here:

The Scrubber SENS developed a few years ago is apparently still ongoing though they have not worked out how to target Senescent T Cells only using cell surface markers, It is apparently part of SENS backed research into heterochronic plasmapheresis program at UC Berkeley according to Michael Rae from SENS. 

I could see a blood scrubber that balances blood factors and removes senescent cells as being a very good step towards rejuvenation. 


From: “” To: steve hill ; Gerontology Research Group Sent: Saturday, 14 February 2015, 15:09Subject: RE: [GRG] Cellular Senescence: senolysis

Is there evidence that regular or acute blood donation can improve health?  I bet there is, but if so, it is surprising that such studies are not more advanced by the ever-thirsty bloodmobilers.  I wonder what the optimum quantity and frequency would be?  If someone has a link, please post it.  Donating blood might well be quicker and easier for purging some of the blood baddies, especially any that simply have no easy exit in the normal elimination system.  Perhaps we will be unrolling the parchments of our blood-letting forebearers to establish starting points for the next big rejuvenation fad!

Walt C.   


About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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