Re: [GRG] Cellular Senescence: senolysis

I agree with your suggestion that combining a “scrubber” to reduce elevated factors in the plasma of aged recipients combined with supplementation of factors reduced in the plasma would go some way toward extension of healthspan, and possibly lifespan.
Difficulties would be the different half-lives of the various factors and how to counter their clearance or inactivation and therefore how often to transfuse or “scrub” the plasma. Difficult, but not impossible…

On Sun, Feb 15, 2015 at 2:11 AM, steve hill wrote:

Any effects should be seen whenever an older person gets young blood via transfusion in theory. It is likely that the effects have not really been studied as it is such a routine procedure, its only recently people have seemed to be looking closer at blood and its effect on older systems when receiving younger blood. 

The problem with transfusions would be the amount likely required so the young factors would need to be identified, synthesized and the blood would need to be correctly balanced in order to emulate young blood. 

Scrubbing and emulating youthful blood are of course two different therapies but it could be combined potentially to scrub and filter/balance the blood. The blood scrubbing would be primarily to remove Senescent T Cells to repair aging damage in the case of the SENS scrubber. Removing Senescent cells would then stop SASP which is a major cause of aging damage, so developing this would be a very good thing for living healthier and longer.

From: Thomas Coote To: Gerontology Research Group Sent: Saturday, 14 February 2015, 21:11

Subject: Re: [GRG] Cellular Senescence: senolysis

Hi Walt,
Yes, evidence exists that blood donations are associated with better health.
In this paper:
blood donors had reduced iron stores and reduced insulin levels, but increased insulin sensitivity.
In this paper:
blood donors showed overall a decreased risk of cancer.Depletion of excess iron stores is generally regarded as beneficial, especially for men.

In Australia, whole blood donations are limited to every 12 weeks.


Tom Coote

On Sat, Feb 14, 2015 at 6:09 PM, wrote:

Is there evidence that regular or acute blood donation can improve health?  I bet there is, but if so, it is surprising that such studies are not more advanced by the ever-thirsty bloodmobilers.  I wonder what the optimum quantity and frequency would be?  If someone has a link, please post it.  Donating blood might well be quicker and easier for purging some of the blood baddies, especially any that simply have no easy exit in the normal elimination system.  Perhaps we will be unrolling the parchments of our blood-letting forebearers to establish starting points for the next big rejuvenation fad!

Walt C.   


About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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