I agree with your suggestion that combining a “scrubber” to reduce elevated factors in the plasma of aged recipients combined with supplementation of factors reduced in the plasma would go some way toward extension of healthspan, and possibly lifespan.
Difficulties would be the different half-lives of the various factors and how to counter their clearance or inactivation and therefore how often to transfuse or “scrub” the plasma. Difficult, but not impossible…
On Sun, Feb 15, 2015 at 2:11 AM, steve hill wrote:
Any effects should be seen whenever an older person gets young blood via transfusion in theory. It is likely that the effects have not really been studied as it is such a routine procedure, its only recently people have seemed to be looking closer at blood and its effect on older systems when receiving younger blood.
The problem with transfusions would be the amount likely required so the young factors would need to be identified, synthesized and the blood would need to be correctly balanced in order to emulate young blood.
Scrubbing and emulating youthful blood are of course two different therapies but it could be combined potentially to scrub and filter/balance the blood. The blood scrubbing would be primarily to remove Senescent T Cells to repair aging damage in the case of the SENS scrubber. Removing Senescent cells would then stop SASP which is a major cause of aging damage, so developing this would be a very good thing for living healthier and longer.
From: Thomas Coote To: Gerontology Research Group Sent: Saturday, 14 February 2015, 21:11
Subject: Re: [GRG] Cellular Senescence: senolysis
Yes, evidence exists that blood donations are associated with better health.
In this paper:http://ift.tt/1CtmcFk
blood donors had reduced iron stores and reduced insulin levels, but increased insulin sensitivity.
In this paper:http://ift.tt/1Da63aJ
blood donors showed overall a decreased risk of cancer.Depletion of excess iron stores is generally regarded as beneficial, especially for men.
In Australia, whole blood donations are limited to every 12 weeks.
On Sat, Feb 14, 2015 at 6:09 PM, wrote:
Is there evidence that regular or acute blood donation can improve health? I bet there is, but if so, it is surprising that such studies are not more advanced by the ever-thirsty bloodmobilers. I wonder what the optimum quantity and frequency would be? If someone has a link, please post it. Donating blood might well be quicker and easier for purging some of the blood baddies, especially any that simply have no easy exit in the normal elimination system. Perhaps we will be unrolling the parchments of our blood-letting forebearers to establish starting points for the next big rejuvenation fad!