Re: [GRG] Newest member Harold Katcher PhD

Sorry this reply from Harold should have gone on GRG 😦

From: Dr. Harold Katcher To: steve hill Sent: Thursday, 26 February 2015, 16:35Subject: Re: [GRG] Newest member Harold Katcher PhD

Hi Steve,
As old organs function the life of the host when transplanted into young donors – they must make changes on the cellular and molecular levels to allow that to happen – otherwise the inter- intra- cellular junk that accumulated would not allow that to happen – ditto the accumulated DNA lesions, the shortened telomeres etc. I think the rejuvenated cell can get rid of all the junk. Also, though the work has never been done to show it – it must be the case that even the telomeres lengthen to allow the old organ to persist years after donation. That does happen when cells are induced to pleuripotence – their telomeres lengthen – so maybe telomere length of stem cells does increase with rejuvenation. Otherwise I agree that something that elicited mTERT action would be an addition. While telomeres seem to have a clock function in our cells – the same is not true of mice (at least up until the very end) – yet the mice age and die. I think telomeres are one of the clocks and that they are reset-able, but there are others. Aging and death have been with us (and I’m sure they were a great invention that allowed the present world’s diversity and our own emergence) from the time of the ciliates and is woven into the fabric of life- disentangling it will be difficult. I also believe that the lives we are ‘given’ are not a grab-bag of genes but a four-dimensional existence with a beginning and end (not fixed)- and a variant of the lives given all mammals (all animals) – that is we are given a life and the rate that life progresses is a variable – the sort of variable that can be controlled by ‘clock speed’, and our place in that life scenario – the act and scene we are in (so to speak), is determined by the body (and carried by the blood) , but can be changed. I think too much emphasis has been placed on the ‘aging’ cell – which I don’t think is even the case – I believe that cellular age is determined by the cell’s environment. I know it sounds crazy – but that the way the evidence points. If anyone is interested I have another paper (one not yet published) that fleshes out this thought.
I have a protocol for the experiments – there are a few differences between it and ‘ordinary’ plasma exchange so I’d like to test safety first – I also have several volunteers (of course what happens to those volunteers when push comes to shove, I don’t know). 

As for combining it with telomerase activation, each technique should be tested on its own – to me the blood sets cellular age and factors like telomere length and mitochondrial functioning are consequences of cellular age and should change accordingly.  




About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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