Sorry this reply from Harold should have gone on GRG 😦
From: Dr. Harold Katcher To: steve hill Sent: Thursday, 26 February 2015, 16:35Subject: Re: [GRG] Newest member Harold Katcher PhD
As old organs function the life of the host when transplanted into young donors – they must make changes on the cellular and molecular levels to allow that to happen – otherwise the inter- intra- cellular junk that accumulated would not allow that to happen – ditto the accumulated DNA lesions, the shortened telomeres etc. I think the rejuvenated cell can get rid of all the junk. Also, though the work has never been done to show it – it must be the case that even the telomeres lengthen to allow the old organ to persist years after donation. That does happen when cells are induced to pleuripotence – their telomeres lengthen – so maybe telomere length of stem cells does increase with rejuvenation. Otherwise I agree that something that elicited mTERT action would be an addition. While telomeres seem to have a clock function in our cells – the same is not true of mice (at least up until the very end) – yet the mice age and die. I think telomeres are one of the clocks and that they are reset-able, but there are others. Aging and death have been with us (and I’m sure they were a great invention that allowed the present world’s diversity and our own emergence) from the time of the ciliates and is woven into the fabric of life- disentangling it will be difficult. I also believe that the lives we are ‘given’ are not a grab-bag of genes but a four-dimensional existence with a beginning and end (not fixed)- and a variant of the lives given all mammals (all animals) – that is we are given a life and the rate that life progresses is a variable – the sort of variable that can be controlled by ‘clock speed’, and our place in that life scenario – the act and scene we are in (so to speak), is determined by the body (and carried by the blood) , but can be changed. I think too much emphasis has been placed on the ‘aging’ cell – which I don’t think is even the case – I believe that cellular age is determined by the cell’s environment. I know it sounds crazy – but that the way the evidence points. If anyone is interested I have another paper (one not yet published) that fleshes out this thought.
I have a protocol for the experiments – there are a few differences between it and ‘ordinary’ plasma exchange so I’d like to test safety first – I also have several volunteers (of course what happens to those volunteers when push comes to shove, I don’t know).
As for combining it with telomerase activation, each technique should be tested on its own – to me the blood sets cellular age and factors like telomere length and mitochondrial functioning are consequences of cellular age and should change accordingly.