Re: [GRG] Newest member Harold Katcher PhD

Dear Harold and all,

 

Interesting paper with which I agree largely though I do feel that some elements of aging are caused by accumulated damage as well as programmed changes. Aging crosslinks, Plaques and other accumulated junk may not be mitigated totally (or at all) even if rejuvenation to a youthful state happens. That said it would go a long way towards health if rejuvenation works as i suspect it may in humans.

 

A few thoughts:

 

1: Supply and demmand: How can we create enough supply of Plasma to meet demmand? Identifying, creating and trying to balance all the factors in blood, taking into account their half lives etc… would be very complex compared to using Plasma so what is the alternative? I have seen a proposal for a dialysis type arrangement but again this means blood factors would need to be filtered and balanced. The ideal would be using your own blood rather than relying on others but how realistic is that?

 

2: Mixed results: I believe an experiment with Plasma in mice yielded inconclusive results not long ago http://ift.tt/1yz01KJ. Admittedly the researchers said it could have been due to the type of Plasma technique used, mouse strain etc… I note they recorded no increase in T-Cell presence which one would expect if the immune system was rejuvenated. Perhaps the frequency of treatment was insufficient or not long enough to create a stable phenotype/environment?

 

Edouard Debonneuil I believe was involved in the study and I am sure I have seen him active on GRG, perhaps he could comment further?  

 

In contrast other studies showed robust rejuvenation in mice such as shown by Conboy, Wyrss-Corey etc… I believe the Thymus in one study was also rejuvenated though the paper eludes me.

 

3: Further study: Definately needs further study ideally in Humans plus Plasma is already a safe and approved medical procedure. I would be interested to hear your plan of action Harold and how you think work in this area could move forward.

 

 

 

Steve

 

 

From: Dr. Harold Katcher To: steve hill ; Gerontology Research Group ; Gerontology Research Group Sent: Wednesday, 25 February 2015, 18:54Subject: Re: [GRG] Newest member Harold Katcher PhD

Hi Steve and all,
Yes there’s no doubt that there are substances that increase and those that decrease during aging in mammals (at least). Both lists of chemicals are however incomplete as we don’t know all of the substances in the blood and have no way of knowing whether they increased or decreased. So for example – membrane-bound ‘exosomes’ – packages of miRNA (important in controlling the extent of translation of messengers) are released into the blood and and taken up by other cells. Those other cells have their behaviors (in terms of translation) changed by the exosomes taken up. So two years ago you might never have heard of miRNA containing exosomes. Do they increase or decrease during aging? That is not even an ask-able question as the contents of those exosomes undoubtedly change during aging – as the miRNA populations are known to change during aging (and in other circumstances as well – like cancer).  Are there other things apart from miRNA-containing exosomes that we don’t know about?  Who knows (and anyone that assumes they do is making an assumption that many others have made throughout the years and have been shown wrong based on later discoveries of new blood-borne factors).  So I wouldn’t presume….  On the other hand there is a way to change old blood so that it exactly mirrors young blood – and preliminary experiments shows that it works to produce rejuvenation.  If anyone is interested – and I think this is the real beginning of our ability to control aging – please read my paper, “Studies that shed a new light on aging” at http://ift.tt/1EfWK85  or if that’s no good just do what I did and Google, “Harold Katcher  studies that shed a new light on aging” – it comes right up.

Sincerely,

Harold

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About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. http://www.AgingIntervention.org Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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