Interesting paper Harold I found a copy here with no paywall:
We have talked about transfusions on here recently and GDF-11 as well as plasma to rejuvenate the aging body. You mention there is a way to change old blood so it mirrors young blood, how could this be possible without knowing all the blood factors and the levels they need to be up and down regulated?
Also whilst fairly compelling that blood factors do control the phenotype and environment and there is good evidence of rejuvenation in mice there are still other aging issues like Telomeres becoming too short and becoming unstable or unable to divide. I do wonder if lengthening the Telomeres combined with blood factors could create a very powerful rejuvenation effect? I know Dr Blau has recently found out how to activate Telomerase in Human skin cells via a transient RNA factor. I noted in a parabiosis and plasma study that mice whilst gaining rejuvenated organs etc… overall gained no lifespan increase, this would seem to suggest other factors at at play, Telomeres perhaps?
Also if the plasma can restore a younger phenotype is a reasonable to assume that the body would then be able to remove damage such as plaques (Brain and Arterial) and other accumulated waste? I think it would be reasonable to anticipate that a rejuvenated immune system would be more efficient at removing senescent cells for example.
Obviously its all theory though until we can get research underway.
From: Dr. Harold Katcher To: steve hill ; Gerontology Research Group ; Gerontology Research Group Sent: Wednesday, 25 February 2015, 18:54Subject: Re: [GRG] Newest member Harold Katcher PhD
Hi Steve and all,
Yes there’s no doubt that there are substances that increase and those that decrease during aging in mammals (at least). Both lists of chemicals are however incomplete as we don’t know all of the substances in the blood and have no way of knowing whether they increased or decreased. So for example – membrane-bound ‘exosomes’ – packages of miRNA (important in controlling the extent of translation of messengers) are released into the blood and and taken up by other cells. Those other cells have their behaviors (in terms of translation) changed by the exosomes taken up. So two years ago you might never have heard of miRNA containing exosomes. Do they increase or decrease during aging? That is not even an ask-able question as the contents of those exosomes undoubtedly change during aging – as the miRNA populations are known to change during aging (and in other circumstances as well – like cancer). Are there other things apart from miRNA-containing exosomes that we don’t know about? Who knows (and anyone that assumes they do is making an assumption that many others have made throughout the years and have been shown wrong based on later discoveries of new blood-borne factors). So I wouldn’t presume…. On the other hand there is a way to change old blood so that it exactly mirrors young blood – and preliminary experiments shows that it works to produce rejuvenation. If anyone is interested – and I think this is the real beginning of our ability to control aging – please read my paper, “Studies that shed a new light on aging” at http://ift.tt/1EfWK85 or if that’s no good just do what I did and Google, “Harold Katcher studies that shed a new light on aging” – it comes right up.