Welcome to Harold and I am looking forward to hearing more.
On the subject of blood factors I borrowed this from Josh Mittledorf’s blog ( I hope he wont mind) which shows some factors that differ in young and old blood:
Blood factors that we have too little of as we get older
melatonin, from pineal gland, controls daily cycle of sleep and waking
DHEA = dehydroepiandrosterone is a precursor of sex hormones and steroids
ubiquinone = CoQ10 is an anti-oxidant and electron transporter, used in mitochondria for energy production
thyroxine, produced in the thyroid, regulates many other hormones, stimulates activity
HSP70, heat shock protein, protects against muscle loss with age
progesterone, involved in menstruation, sleep cycle, mood; downregulates growth, increases insulin sensitivity
(HGH = human growth hormone)
(testosterone) primary male sex hormone
(estrogen) several primary female sex hormones
Blood factors that we have too much of as we get older
Wnt, a growth promoter associated with cancer
NFkB, a cytokine which triggers inflammation
LH (luteinizing hormone) & FSH (follicle-stimulating hormone), associated with ovulation in women and sperm production in men. Increase late in life for both men and women.
Estradiol, a female sex hormone
CCL11 (a growth-inhibiting chemokine, see Villeda’s work above)
You can add Klotho, Oxytocin and GDF-11, FOXN1 to this list though in what amounts I could not say.
The original article is here: http://ift.tt/1mi65AS
From: “John M. “Johnny” Adams, GRG Exec Director” To: ‘Gerontology Research Group’ Sent: Wednesday, 25 February 2015, 16:11Subject: [GRG] Newest member Harold Katcher PhD