Unfortunately it does seem the repair effect is on existing Nephrons and tissue rather than creating new one, so it would improve the ability of the Kidney to function but not rebuild it totally.
From: Michael Price To: Gerontology Research Group ; steve hill Sent: Wednesday, 4 March 2015, 9:10Subject: Re: [GRG] Kidney donor ages…
That link seems to be taking about cells, not nephrons. Are new nephrons appearing? Or is it just existing nephrons repairing themselves?
On 4 Mar 2015 08:37, “steve hill” wrote:
I think this got lost in the noise before but relates to Kidney regneration and its ability to repair itself.
Stanford recently found out the Kidney does rejuvenate throughout life
WNT Signalling appears to offer a way to encourage regeneration and is presumably a protein that is present in younger blood. If this protein could be introduced then regeneration would be possible in theory.
From: Dr. Harold Katcher To: Mike Darwin Cc: Gerontology Research Group ; Greg Fahy ; roy yowell Sent: Wednesday, 4 March 2015, 6:06Subject: Re: [GRG] Kidney donor ages…
The story is not clear in my mind as to whether stem cells in old patients can function in an environment shown to “age” stem cells, (change their age-phenotype in terms of some criteria like time to complete cell division or having age-specific DNA methylation patterns to resemble what is shown by an older population of the same cell type) stem cells both in vitro and in vivo. . However what about adding plasma replacement to stem cell transfers? That might modify the internal environment in such a way as exogenous stem cells could be accommodated – without serum factors causing them to become old.