Re: [GRG] Kidney donor ages…

Unfortunately it does seem the repair effect is on existing Nephrons and tissue rather than creating new one, so it would improve the ability of the Kidney to function but not rebuild it totally.

From: Michael Price To: Gerontology Research Group ; steve hill Sent: Wednesday, 4 March 2015, 9:10Subject: Re: [GRG] Kidney donor ages…

That link seems to be taking about cells, not nephrons.  Are new nephrons appearing?  Or is it just existing nephrons repairing themselves?

regards
Michael

On 4 Mar 2015 08:37, “steve hill” wrote:

 

I think this got lost in the noise before but relates to Kidney regneration and its ability to repair itself.

 

Stanford recently found out the Kidney does rejuvenate throughout life

 

http://ift.tt/1AZqXHn

 

WNT Signalling appears to offer a way to encourage regeneration and is presumably a protein that is present in younger blood. If this protein could be introduced then regeneration would be possible in theory.

Steve 

From: Dr. Harold Katcher To: Mike Darwin Cc: Gerontology Research Group ; Greg Fahy ; roy yowell Sent: Wednesday, 4 March 2015, 6:06Subject: Re: [GRG] Kidney donor ages…

Hi Mike,

The story is not clear in my mind as to whether stem cells in old patients can function in an environment shown to “age” stem cells, (change their age-phenotype in terms of some criteria like time to complete cell division  or having age-specific DNA methylation patterns to resemble what is shown by an older population of the same cell type) stem cells both in vitro and in vivo. . However what about adding plasma replacement to stem cell transfers? That might modify the internal environment in such a way as exogenous stem cells could be accommodated – without serum factors causing them to become old.
Sincerely,

Harold

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About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. http://www.AgingIntervention.org Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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