Re: [GRG] Kidney donor ages…

Steve et al,
Sorry to say this but there’s so much we don’t know – and worse, so much we think we know but do not.  The work of Amy Wagers on heart rejuvenation using heterochronic parabiosis showed that the dormant and apparently non-functional cardiac stem cells could be made to function so as to strengthen the heart – when for many years no one thought these cells important. One question that often arises with discussions of life extension (in my Biology of Aging class) is whether rejuvenated women might be able to produce babies. The standard medical answer would be “no”, simply because it is believed that women are born with their full quota of ova already stuck in the first meiotic metaphase at birth. However this is not strictly fact. Lord Solly Zuckerman ‘ruled’ that the model of all ova already being formed by birth and waiting in stasis for the hormone surge that would send them through meiosis and produce the ovum that would eventually go down the fallopean tube is a reasonable hypothesis based on the evidence (in the early 1950’s), not a matter of fact.  The facts is (are) that subsequent studies in mice at least suggest that new ova are created throughout the fertile life of female mice. Which picture is the true one? In retrospect I can’t imagine that a cell can be stuck in metaphase I for decades, all its genes hidden from intracellular machinery by the compaction of the chromosome – even with nurse cells (if they do so) to feed the quiescent metaphase I ova – I still can’t imagine how a cell could maintain itself in that state for decades. I can’t remember the source (time for rejuvenation!), but some editorial somewhere said something like, “If we can’t accept this model (wrong though it be) then we have no explanation at all!”   The implication being that it’s better to have a bad model than no model at all – which I think is exactly the opposite of the truth. Having a wrong model heavily ‘believed in” is much worse than having no model – because it leads you in the wrong direction – while not having a model may keep you in the same place until you do have one, and one that works. I think this is the case with aging, our ‘wear and tear’ models have led us in the wrong direction – trying to patch the lesions occurring during aging instead of aiming at the source of those lesions – which turn out to be self-imposed.  Like fighting ISIS by sending in ambulances to repair the wounds inflicted by their soldiers on ours. 
Sincerely,

Harold

Advertisements

About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. http://www.AgingIntervention.org Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
This entry was posted in Uncategorized and tagged , , , . Bookmark the permalink.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s