Re: [GRG] Kidney donor ages…

Hi Mike,
Fascinating (in homage to Mr. Spock) – but really. Makes me wonder if as in the case of the heart there aren’t nephrogenic stem cells lurking – ineffective now – but perhaps activated by exogenous factors to restore this ability to form new nephrons….? We’ve recently discovered stem cells in mice that respond to influenza damage to the lungs to reform the lung epithelium; are they present in humans?  No one knows.  In any case, at some point we’ll know what we have to do to get stem cells to form nephrons – and we’ll know enough to get them to grow functionally in kidneys. We already know that it is possible to make our own cells into stem cells – one of the great benefits of (sorry, but it’s true) restricting embryonic stem cell use. So really all of us are potentially immortal in that we can be cloned from our own cells over and over again. However I would not walk into a Star Fleet ‘transporter’ under the notion that whatever came out the other side, though it talked, walked, looked, and acted like me, it wouldn’t be me, I’d have been atomized. So I’d like to live my life in this body with a constantly renewed brain (so, you’d forget the unimportant parts – so what?) and renewed organs. Some changes might take surgery or even robots or nanobots, but I think if work done in the past is true then HPE (Heterochronic Plasma Exchange) will work well enough at least to give us the time we need to receive the ultimate enhancements. So far, transplantation and heterochronic parabiosis experiment have shown that the organs that are regenerated include the brain, liver, immune and blood-forming (hematopoietic) systems, heart and muscles. Now that does leave some biggies – most notably the peripheral nervous system, but who knows what can be done about that. I say we think we know it all and then we examine a fly and find that like it, we too have toll-like receptors important to our immune system> How long ago were  innate lymphoid cells discovered? In all there are estimated to be a thousand different sorts of immune cells.  And yet we know very little. The recent “roadmap to epigenetics’ published in Nature this week, shows that there are hundreds of thousands of enhancer regions, we know that there are protein kinases that phosphorylate thousands of protein types – we see enzymes that turn into transcription factors when they don’t get enough substrate – what I’m saying is that even at the level of the cell life is more complex and unknown than we now understand, so do you imagine it should be less so at the level of the body?   That was the problem with aging research – they started out with the simplistic but insightful idea that aging was the loss of information and structure to entropy – and could never leave the moat they had dug for themselves.


About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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