[GRG] Plasma Factors and aging

With apologies to my esteemed friends, here are a few thoughts I have had regarding the proposal of plasma exchange. They will probably be quite laughable but I welcome your constructive comments.
Cheers,
Thomas…………………………….
The work by
Amy Wagers and Irina Conboy and others gives us tantalising hope that exchanging
old plasma for young may help rejuvenate at least some tissues of the human body.

Although
the example of a kidney transplanted from an old donor to a young recipient is
the closest we have to a rejuvenation “experiment”, it is a flawed experiment
as the donated kidneys are subjected to sustained attack by the host immune
system (albeit dampened by drugs.)

In a recent
experiment, Shytikov et al (2014) failed to extend the lifespan of mice beyond
controls with frequent injections of plasma from young mice. One possible
explanation for that result is as follows:

 

Assuming
that aging is caused by an imbalance of plasma-borne factors (that is; some
present in excess, a paucity of others), the aim of the plasma exchange would
be to rebalance the factor profile to that of a young mouse.

Lower
levels of a factor may be due to lower transcription rates, lower translation
rates, post-translational modification, inactivation, receptor binding, higher
excretion rates or other unidentified reasons.

Conversely,
higher plasma levels of a factor may be due to higher transcription or translation
rates, receptor scarcity or receptor inactivation, loss of inhibiting factors, lower
rates of excretion or still other unknown reasons.

Youthful plasma
introduced to the old animal should begin to have effects almost immediately,
but, conversely, the old body will be “working” to return the plasma to
pre-exchange levels.

Thus,
another plasma exchange will be necessary well prior to this stage in order to
maintain the effect. (In other words, to mimic as closely as possible
hetereochronic parabiosis, a continuous process.)

Thus, one
possible explanation for the result is that the exchange volume was too little
and not often enough.

One must
consider, also, that mice age many times faster than humans, so it is possible
that their “control mechanisms” drift from optimal levels much faster than those of humans. (Conversely, as humans age much more slowly than mice, perhaps plasma transfusions will be more effective in slowing aging?)

One way to
explore this might be to identify the factors that give the most “weight” to
aging in humans and then measure their typical rates of production and
destruction. This might allow an estimate of the minimum period between plasma
exchanges to be calculated.

 

REFERENCE

 

Shytikov, D., Balva, O., Debonneuil,
E., Glukhovskiy, P. and Pishel, I.

Aged Mice Repeatedly Injected with
Plasma from Young Mice:

A Survival Study. BioResearch Open
AccessVolume 3, Number 5, October 2014.

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About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. http://www.AgingIntervention.org Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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