Re: [GRG] My recent audio interview with Justin Loew of Longecity Now

Dear Johnny, 

I listened to your piece and you sounded very good – I like your approach and I didn’t miss that plasma exchange came first on your list of “flagship” projects – as well it should. There’s hardly any field of research that is more suited to humans than to animals; the existing equipment for plasmapheresis and plasma exchange is made, (and medically approved), for humans and not animals (though it might be okay for large dogs, pigs, etc.).

As the only approach demonstrated to reverse aging, in situ, in living animals, without requiring genetic engineering, nor requiring any technological break-through  whatsoever – with admittedly only ‘circumstantial evidence – and (Edouard) some contradictory evidence that is minimally relevant (as the procedures will differ enormously). – but it is the gamble ( a relatively cheap one, according to how rich you are).

There are still some technical questions that need to be asked – as for example; are there effective means of storing plasma/serum long-term? But of course the biggie will be the biomarkers; I think I’ve picked appropriate ones – as those which are the most conservative according to a paper by the most conservative of critics of programmed aging, Tom Kirkwood. So while telomere length would be a nice thing, there’s no good correlation among 85+year old’s life expectancy and telomere length. Some cruder criteria like  total hemoglobin concentration are called for. I would really like to see DNA and epigenetic studies of rejuvenated cells, and we can see if we can get some cooperation with people doing that work (money talks). In humans you can judge  age relatively, and in the only way that matters, by peoples appearance – a trait that we’re not adept at judging in animals so we should use that. We also would want to study the chronic inflammation associated with aging, following the standard biomarkers in the blood – like CRP (‘c-reactive protein) etc  An interesting question I think was made by Amy Wagers about GDF11 not ‘de-aging’ the body but repairing it. I believe Amy belongs to the ‘wear and tear’ school of aging which likes aging cells to damaged cells – so by that definition, what is the difference between repairing cells and ‘de-aging’ them? – if aging is damage, then ‘de-aging’ would be the repair of damage. Truth is that you can ‘de-age’ cells – you can de-age nuclei (‘rejuvenate’ is a better term) by inducing them to pleuripotence – using transcription factors or even small molecules). and that changes their age phenotype – even changing their telomere lengths and transcription patterns (obviously), making their mitochondria efficient, producing more ATP and fewer ROS. Evidence is that organs transplanted serially can last multiples of their original lifespans – and knowing that a thymus can go back to functionality after involution guarantees that age-phenotype at the organ level is controlled by the plasma; that it can last the life of a new host after being brought back signals another lifespan at least (if you wait until you’re old). But if it’s true – then  the young could benefit even more- there’s no better way (that I can think of) of avoiding the diseases of aging than by not aging. Well we’ll see.

Sincerely,

Harold

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About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. http://www.AgingIntervention.org Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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