Re: [GRG] FW: Quantifying the Effectiveness of Anti-Aging Interventions

True, as I noted to MD elsewhere, the effect is less for those with normal homocysteine levels.  Still positive, though.  Only a 3-fold combo, so we can’t expect too much.

regards
Michael

Hi Michael,

Re: And a combination of *just* B-vitamins reduced the grey matter atrophy rate by sevenfold – in humans  

Nice reference…  one note is that the 7-fold ratio only includes regions where B vitamins seemed to work (including some significant ones like hippocampus and others it states are involved with AD), and the regions where such marked changes occurred are much smaller in people who have normal homocysteine levels.  Regarding total gray matter loss, the difference over 2 years is 2% in placebos vs. 1.4% in the B vitamin group.  

Best regards,

Bobby

 

On Thu, Feb 26, 2015 at 10:24 AM, Michael Price wrote:

Hi Mike,

Thanks for the LEF Mitochondrial Optimizer anecdote.  I also take it, although with no adverse effects, perhaps because I missed the nettle extract version.

Hypothesis: Spindler’s results are negative because he uses too narrow a range of supplements, even when he includes LEF mix.

By contrast, the more comprehensive Rollo supplement, which reversed brain atrophy, also extended rodent lifespan.

And a combination of *just* B-vitamins reduced the grey matter atrophy rate by sevenfold – in humans

> “Age associated morbidity and mortality (and thus aging itself) is a logarithmic [process] starting around age 30. This suggests that the effectiveness of almost all currently available “nutraceutical” products will be negligible, or nonexistent, when administered to people younger than age 30.”

Aging does not begin at 30.  Unfortunately this obvious truth seems to escape many, who fondly believe they can wait until 30 (or even 40) before intervening.  But I can’t be bothered to argue this, since I am now considerably over 30.

regards
Michael Price

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About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. http://www.AgingIntervention.org Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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