True, as I noted to MD elsewhere, the effect is less for those with normal homocysteine levels. Still positive, though. Only a 3-fold combo, so we can’t expect too much.
Re: And a combination of *just* B-vitamins reduced the grey matter atrophy rate by sevenfold – in humans
Nice reference… one note is that the 7-fold ratio only includes regions where B vitamins seemed to work (including some significant ones like hippocampus and others it states are involved with AD), and the regions where such marked changes occurred are much smaller in people who have normal homocysteine levels. Regarding total gray matter loss, the difference over 2 years is 2% in placebos vs. 1.4% in the B vitamin group.
On Thu, Feb 26, 2015 at 10:24 AM, Michael Price wrote:
Thanks for the LEF Mitochondrial Optimizer anecdote. I also take it, although with no adverse effects, perhaps because I missed the nettle extract version.
Hypothesis: Spindler’s results are negative because he uses too narrow a range of supplements, even when he includes LEF mix.
By contrast, the more comprehensive Rollo supplement, which reversed brain atrophy, also extended rodent lifespan.
And a combination of *just* B-vitamins reduced the grey matter atrophy rate by sevenfold – in humans
> “Age associated morbidity and mortality (and thus aging itself) is a logarithmic [process] starting around age 30. This suggests that the effectiveness of almost all currently available “nutraceutical” products will be negligible, or nonexistent, when administered to people younger than age 30.”
Aging does not begin at 30. Unfortunately this obvious truth seems to escape many, who fondly believe they can wait until 30 (or even 40) before intervening. But I can’t be bothered to argue this, since I am now considerably over 30.