Dear Johnny (and all),
As proposed I have read the article and tried to summarized here and indicate the next steps as it looks very impressive to me:
In very short and going straight to next steps: they report that **** a single gavage of 5 mg/kg bw Dadatinib +50 mg/kg bw Quercetin eliminates scenescent cells and improves various functions for long **** in various models of aging in mice (essentially accelerated models), and hope that it could be tested in non human primates.
The single adminstration is notable for the possibility to minimize toxicity.
seemingly clear next steps:
— by coincidence, **** would anyone here be in a possibility to test the treatment in aged primates? **** (with a health indicator to be defined)
— @dear Johnny/@a contact in the lab, is the lab planning to do a rodent lifespan study? (In non progeroid animals). The frequency of gavage might have to be well chosen.
[Ps: what impressed me also is how logical biology has revealed to be in that study; from the initial assumption that killing senescent cells is good, to choosing the treatment based on bioinformatics, then based on vitro tests then in vivo tests. Do we only read the positive results? Even if so, still quite impressive results]
Envoyé depuis un mobile Samsung.