With my increased fascination with human genomes in the past year, I just saw this article:
While this is not directly related to aging, but since combating and curing various diseases would help improve the aging process, I saw this snippet of interest for this group:
“”This is an exceptional new research finding that opens the door to an entirely new area of exploration in human genetics,” said Fernando Pardo-Manuel de Villena, PhD, professor of genetics and senior author of the paper. “We’ve known that there are 95 genes that are subject to this parent-of-origin effect. They’re called imprinted genes, and they can play roles in diseases, depending on whether the genetic mutation came from the father or the mother. Now we’ve found that in addition to them, there are thousands of other genes that have a novel parent-of-origin effect.”
These genetic mutations that are handed down from parents show up in many common but complex diseases that involve many genes, such as type-2 diabetes, heart disease, schizophrenia, obesity, and cancers. Studying them in genetically diverse mouse models that take parent-of-origin into account will give scientists more precise insights into the underlying causes of disease and the creation of therapeutics or other interventions.”
Would this possibly partly explains why females generally outlive males, or is that comparing apples and oranges (i.e. just because a child may inherit more genes for complex diseases *from their father*, since the child can be of either gender, the impact should be minimal)?
Mark E. Muir
Technical Support Database Administrator
Gerontology Research Group