On 03/11/2015 06:20 AM, Mike Darwin wrote:
> Does anyone know what fraction of cells are senescent vs. age?
Primate numbers from back a ways:
So probably only in the ballpark, especially given better tools and
understanding to identify senescent cells.
This recent drug study in mice seems to be claiming 20-50% clearance
rates at best in old mice, but varying widely in tissues, and some
approaches not doing much. Which leads me to think that this is probably
going to be another case of a much smaller effect in people. But that
shouldn’t be technically hard to pin down with a short trial in humans
and a tissue same at the beginning and end.