Re: [GRG] Dasatinib + Quercetin eliminate senescent cells

As an FYI, here are the discounted prices for thirty 100 mg Sprycell (dasatinib) tablets in the U.s. using GooodRx coupons:

Kmart

View store details

9,835.41with free coupon

Walmart

View store details

9,877.95with free discount

Walgreens

View store details

10,961est. cash price

9,928.04with free coupon

Vons Pharmacy

View store details

10,052.60with free coupon

Rite-Aid

View store details

12,718est. cash price

10,545.09with free coupon

If it is assumed you need 1 week of treatment per cycle, that would require a minimum of 2 tablets, and more likely 3, to take into account losses from pulverizing and subdividing the 100 mg tablet dose into seven 30 mg doses. That comes to roughly $330 per tablet, or just about $1,000 per cycle. I’m assuming that continuous therapy is neither desirable nor affordable, which is a somewhat arbitrary assumption on my part. A reasonably number of cycles per year might be quarterly or biannually.

Prices from an online Indian pharmacy for 50 mg tablets are:

http://ift.tt/1FRN7eO

Dasatinib 50 mg Tablet (Brand SPRYCEL 50)

Your Cart 

           

Pack Size

Price / Pack

Price / Unit 

Great Discounts on the MP*

60 tablets

USD 5058

USD 84.30

*Minimum Pack Minimum Price %

Add to Cart

120 tablets

USD 9953

USD 82.94

SAVE 2 % on the MP

Add to Cart

240 tablets

USD 19704

USD 82.10

SAVE 3 % on the MP

Add to Cart

480 tablets

USD 39004

USD 81.26

SAVE 4 % on the MP

Add to Cart

Being realistic, comparatively few Westerners past middle age weigh 75 kg, so a 50 mg QD dose is probably more realistic. If a group purchase is assumed so that you pay for just the 7 tablets required for one cycle (a lot of assumption here!) then the cost per cycle would be in the ball park of $625-650, assuming some over overhead for redistribution, such as repackaging and reshipping in country.  

I use the above pharmacy only as an example. I have never dealt with them. The most reliable Indian pharmacy I know of is All Day Chemist. They ship promptly, have a virtually zero error rate, and provide drugs, at least the ones I’ve tested, that are genuine and meet their specifications. ADC does not carry Sprycel, but they can usually get a specific, non-controlled drug if the Oder size is sufficiently large.

As an side, this is a Tx I would definitely want to try on a minimum of three dogs of advanced age  while monitoring their clinical chemistries, vital signs, body weight and neurological status before trying this on older humans. 

Anyway, some facts to chew on.

Mike Darwin

Advertisements

About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. http://www.AgingIntervention.org Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
This entry was posted in Uncategorized and tagged , , , . Bookmark the permalink.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s