I have had a thought about how to bound the degree of quercetin/dasatanib induced apoptosis of senescent cells in humans. It should be possible to induce this cutaneously in a 3 x 3 cm area of skin on the left forearm. I suggest the left forearm since in the U.S., and many other countries, drivers have their left side exposed to the sun and thus have more senescent cells and actinic keratoses on that side of their face and forearm. This will be particularly true of people who have spent a substantial portion of their adult life in sunny areas of the U.S.
I would propose oral Tx with quercetin at 500 mg QD for three days prior to topical application of 0.001% dasatinib in a Lipoderm cream base: http://ift.tt/1NOFKKD by a compounding pharmacy. The cream would be rubbed into the skin in a pre-marked area (Sharpie marker) and then be covered with a Tegaderm bio-occlusive dressing:
The duration of Tx is an open question. The time course to apoptotic cell death is variable, but should be apparent in 24 to 48 hours.
This approach would give some indication of the magnitude of response this Tx induces in older humans in general, and perhaps in a given individual, as well.