Re: [GRG] Plasma Factors and aging

I’m all for it as an interesting research plan, but my best guess is that the transfusions will have to be too frequent to be practical.  Most blood factors are being manufactured and broken down constantly, and have a lifetime in the blood stream of hours or even minutes.

I don’t mean to sound authoritative on this, and if someone knows better, I’d be happy to be corrected.
– Josh

On Fri, Mar 13, 2015 at 11:01 PM, Thomas Coote wrote:
Dear Steve & Harold,

I agree with all of your comments and logic and that plasma exchange seems the way forward. Just playing “Devil’s Advocate” to try to hear all positives and negatives. 

Best regards


On Saturday, March 14, 2015, steve hill wrote:

Far better to test the theory using HPE then work out factors at later once proof of concept is made IMO, there are plenty of people doing that already including big pharma but that does not hold back the ground work using full plasma now. Blood contains potentially hundreds of factors as Harold says including good things like GDF-11, Oxytocin, Klotho, FOXN1 plus bad things like pro-inflammatory cytokines.

The key with Harold’s proposal is we do not need to know all the factors in order to test the theory and it is something that we can do right now with very little lead time. Plasma is safe and approved medically so we could begin testing right now, we don’t need to wait decades. 

From: Dr. Harold Katcher To: Gerontology Research Group Sent: Friday, 13 March 2015, 17:45Subject: Re: [GRG] Plasma Factors and aging

Dear Thomas,
I agree that in principle you could filter out the ‘bad’ elements and add the ‘good’ ones, in reality we don’t know either the bad ones (except perhaps CCL11 and some pro-inflammatory cytokines) or the good ones (apart from GDF-11 and oxytocin).  There may be molecules such as miRNAs contained in exosomes that are vital for age-determination – and yet others that we have no idea about. 

I would check my math however – while the formula you use for the replacement of plasma is correct the number you get is wrong. About 1.5 plasma volumes would get you down to around 20% old plasma remaining after a single exchange. One and a half plasma volumes is fairly normal for a plasma exchange. So after two exchanges you are left with ~ 4% old plasma remaining. And that’s not a lot. Imagine that we knew all the factors needed to be changed- my guess is there would be hundreds and the costs would be tremendous.- you’d sill need plasmapheresis to accomplish that – so aside from allergic reactions what would be the advantage – I can easily see the disadvantages? And plasma is used under life-threatening conditions on the battlefield to save lives – without overmuch worry about allergic reactions. 




About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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