Re: [GRG] Plasma Factors and aging

Harold –
    Yes, this is promising.  I do believe that small molecules in the plasma are short-lived.  So if this is working as well as Villeda claims, it means that something added from young blood is reprogramming the epigenetics of other cells in the body – esp endocrine cells – so we’re getting a self-reinforcing effect.

    Of course, I think the experiment is well worth doing, and I hope that it works this way.  But what I’m saying is that the evidence is too thin at this point for me to be confident that it will.

– Josh

On Sat, Mar 14, 2015 at 2:24 PM, Dr. Harold Katcher wrote:

Josh and all,
If you are referring to plasma exchanges as ‘transfusions’, I don’t think you are correct based on the evidence by two experimenters, Saul Villeda and Tony Wyss-Cory. That giving injections equivalent to 5% of total plasma volume in bi-weekly doses over the course of a month had significant rejuvenatory effect means that the factors causing rejuvenation, must have a half life long enough to allow an accumulation of factors in the blood sufficient to cause rejuvenation. (Other wise each injection causes a slight decrease in age phenotype which was cumulative – or else a single injection of 5% of total plasma volume should cause the total rejuvenation – and that isn’t likely).  Add to that the observations by Michael Conboy that in vitro at least, the rejuvenation by young serum (and it was serum, so serum can substitute for plasma (as someone asked) occurred within twenty-four hours (and old stem cell exposed to ‘old’ plasma seemed to age immediately) So then, what constitutes the blood apart from the liver-supplied plasma proteins and the marrow supplied blood cells. Of course all the products that cells, tissues and organs secrete into the plasma. This defines the plasma and it appears from all studies, that these cell, tissue and organ-secreted products in the bloodstream ARE the age-determining molecules. So if a quorum of cells ‘converts’ to a younger age – those cells and the tissues and organs they are a part of secrete as would their younger versions, this would set up a newly stabilized age according to both quorum cellular age-phenotype and the age-determining molecules present in the plasma. My guess is that this will stably reset the body’s age-phenotype. In any case, the changes in brain age used to assess rejuvenation in the Villeda plasma injection experiments were assessed months after treatment so that treatment – way less than I propose to do with HPE – resulted in stable significant rejuvenation months after treatment. In that case how would HPE not work???




About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
This entry was posted in Uncategorized and tagged , , , . Bookmark the permalink.

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s