Apparently everything works by epigenetics and epigenetics is comprised of many things – DNA modifications, histone modifications, chromosomal location in the interphase nucleus, si, mi, lnc, pi, piwi RNAs, and the interaction of complex networks. I don’t believe that there’s a static code that details our eventual aging and death, but I believe the code is an emerging one, directed by both internal and external processes and interactions at all levels of the biological hierarchy – well above our present ability to.
” But what I’m saying is that the evidence is too thin at this point for me to be confident that it will.” At this time four years ago Aubrey de Grey said basically the same thing, but he thought it promising and an experiment that ought to be done. If it had been done at the time …. At the same time a brilliant researcher like Michael Conboy can’t get funding for experiments preceding from the one that made him known. However, since that time, Villeda produced his results showing brain rejuvenation, both functional and structural, Wagers showed rejuvenation of the heart and brain, and Irina Conboy contributed oxytocin as rejuvenating skeletal muscles. So the evidence that makes it clear that this has clinical potential for a variety of aging conditions – it really has yet to be done. I know Wyss-Coray is doing it without any real idea of why (though he admits the possibility of rejuvenation) I think he is just guessing at the principles. And I think he got that from Tom Rando who got it from me.