Would you be able to supply a reference to show that transplanted organs (old to young) can function for two lifetimes?
I understand your reasoning for the process by which this might happen, but I am unable to find a reference to it.
On Sat, Mar 14, 2015 at 9:45 PM, Dr. Harold Katcher wrote:
Please read my response to Josh. The fact that a transplanted organ (transplanted from an aged donor to a young recipient), can live and function for two lifetimes at least informs us that its tissues must have been changed so that they can regain a lost lifetime, that is they become functionally younger and capable of extreme life extension (multiples of the normal lifespan). How could they do that if their telomeres remained at the basal level left them when they were in dysfunctional, aged organs? It must be the case the the telomeres grow back – or how else could the organ last another lifetime? My guess is – based on the same reasoning – that senescent cells will also be eliminated at least once the immune system is rejuvenated – because how could the organ return to full functionality if 15-30% of its cycling cells are senescent? In the absence of immune system rejuvenation (which there is evidence to indicate may take a longer time to rejuvenate than other tissues) perhaps the answer eliminating the stem cells requires additional treatment with senescent-cell eliminating drugs? Like all the other ’causes’ of aging – removing senescent cells gives an increase in life expectancy of about twenty, twenty-five percent. While who would oppose adding a decade or two of healthy years to their lives – I want to go much, much further with increases in lifespan multiples of today’s lifespans.