Re: [GRG] wrap up: 50mg Dasatinib+500mg Quercetin gerotrial ?

I use a lot oral Quercitin in my practice for those with inflammatory disorders especially Atopic complex/Asthma . 

Works well clinically. 

Karlis Ullis, MD 

Karlis C. Ullis, MD


Endocrinology, Sports & Preventive Medicine

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On Sat, Mar 14, 2015 at 11:05 PM, peter cooperrider wrote:

From the standpoint of a Dermatologist, if there is no sophisticated method to easily get them to penetrate into the skin, there are always the readily available and commonly performed “brute force” methods of microneedling with a $1,500 instrument or fractional CO2 laser with a $50,000 instrument before, during, or after application in suitable solutions. It just takes a few minutes to do a whole face.Pete Cooperrider

Date: Sat, 14 Mar 2015 19:44:57 -0400From: josh@mathforum.orgTo: grg@lists.ucla.eduSubject: Re: [GRG] wrap up: 50mg Dasatinib+500mg Quercetin gerotrial ?

what would we typically measure to make an aggregate health indicator and to measure cell senescence and regeneration? how much would it typically cost?

I suggest you contact Luigi Fontana at Wash U in St Louis for this.  He has lots of experience with age markers in humans.

– Josh


On Sat, Mar 14, 2015 at 3:47 PM, Dr. Harold Katcher wrote:

Hi All,Were not quercetin a supplement that is widely used with little apparent effect on lifespan according to studies, why should it extend lifespan now? So apparently because it only extirpates a small spectrum of senescent cell types – and disatanib (note the word “satan” hidden in that) then must be the drug conferring the advantage – or it requires both drugs working in synergy (it’s not let out is it?)?  If quercetin is used by itself – shouldn’t it produce measurable effects on tissues with epithelial origins – like skin?  If so, couldn’t it be applied topically to limited regions of skin to test that effect in humans. Some of you out there specialize in skin products – can the quercetin be made to penetrate down to the basal cells? Maybe dissolving it in DMS, peels, abrasion ? As someone said that alone is worth a fortune. It’s something that could be started tonight.



About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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