Re: [GRG] Few lifespan experiments of Dasatinib or Quercetin

Please see this recent study of quercetin and lifespan in mice by Steve Spindler et al.

Spindler, S. R., Mote, P.
L., Flegal, J. M., & Teter, B. (2013). Influence on longevity of
blueberry, cinnamon, green and black tea, pomegranate, sesame, curcumin,
morin, pycnogenol, quercetin, and taxifolin fed iso-calorically to
long-lived, F1 hybrid mice. Rejuvenation research, 16(2), 143-151.

Author information:
(1)Department of Biochemistry, University of California at Riverside, California
92521, USA. spindler@ucr.edu

Phytonutrients reportedly extend the life span of Caenorhabditis elegans,
Drosophila, and mice. We tested extracts of blueberry, pomegranate, green and
black tea, cinnamon, sesame, and French maritime pine bark (Pycnogenol and
taxifolin), as well as curcumin, morin, and quercetin for their effects on the
life span of mice. While many of these phytonutrients reportedly extend the life
span of model organisms, we found no significant effect on the life span of male
F1 hybrid mice, even though the dosages used reportedly produce defined
therapeutic end points in mice. The compounds were fed beginning at 12 months of
age. The control and treatment groups were iso-caloric with respect to one
another. A 40% calorically restricted and other groups not reported here did
experience life span extension. Body weights were un-changed relative to controls
for all but two supplemented groups, indicating most supplements did not change
energy absorption or utilization. Tea extracts with morin decreased weight,
whereas quercetin, taxifolin, and Pycnogenol together increased weight. These
changes may be due to altered locomotion or fatty acid biosynthesis. Published
reports of murine life span extension using curcumin or tea components may have
resulted from induced caloric restriction. Together, our results do not support
the idea that isolated phytonutrient anti-oxidants and anti-inflammatories are
potential longevity therapeutics, even though consumption of whole fruits and
vegetables is associated with enhanced health span and life span.

PMID: 23432089 [PubMed – indexed for MEDLINE]

On Sun, Mar 15, 2015 at 8:43 PM, Dr. Harold Katcher wrote:

No offense Edouard but the fact that the quercetin-consuming mice lived 10% shorter lives is helpful information. Of course you’ve got to analyze this in terms of the dose and what the dose equivalent in people would be – but I don’t think that’s a good thing to decrease lifespan. At the least if means there’s a limit beyond which more harm than good is done – like most ‘medicines’. Again, we’re tilting at windmill’s each statistical increase in lifespan in mice may have nothing to do with increasing human lifespan. The most important think I think is to realize the a living thing is not just a collection of genes. Yes, there are something like twenty-something thousand proteins, and then with alternate reading frames and differential splicing we might double that number, but there are hundreds of thousands of enhancer regions, and dozens (at least estimates range into the millions) of histone codons, there is the heirarchical organization of the interphase nucleus influencing gene regulation, There is a four dimensional structure to a life – you are not given a collection of genes – those genes are exposed in a partcular order as development proceeds – you become an embryo, a fetus, a neonate, a baby, a todler – and ending with, late middle age, early old age, middle old age, old old age – death) the entire scenario that you are born with – that you act out  throughout your lives. 
I think the bacterial virus T4 most influenced me – it played out its life like a lighted fuse – transcription starting at the 5′ end of the organism and traveling towards the 3′ end. At the 5′ end are all the “early” genes (early early, middle early and late early) that chew apart the host DNA substitute their own sigma factors to direct the host RNA polymerase to viral DNA- and at the 3′-end is the lysozyme gene whose product will lyse the bacterial cell wall (all of this has been taking place in a bacterium), releasing all the progeny.  Now our lives have many more choices – (T4 has none, bacteriophage lambda can choose to be lytic or become a dormant part of the host DNA) – but I think the basic plan is the same – a four dimensional progression. Even when we look at the progression of hemoglobins during development we see the different hemoglobin genes are linearly arrange in the order they appear in the embryo/fetus/newborn.

Sincerely,

Harold

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About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. http://www.AgingIntervention.org Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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