Re: [GRG] Few lifespan experiments of Dasatinib or Quercetin

Hi Craig,

Yes, I like Steve’s fine and original research
very much.

A nice video of him summarizing a study much like
the one you cite is at

http://ift.tt/1BqUyoR

At about 13 minutes and 20 seconds, he said

1.) quercetin was combined with taxifolin and
pycnogenol,

2.) they’re similar compounds, and

3.) they had no effect on life span.

However, I have not read the article you cite in Rejuvenation
Research, which may say something different.

I hope that helps,
Kingsley

On 03/16/15 02:09, Craig Cooney wrote:
> Please see this recent study of quercetin and lifespan in mice by
> Steve Spindler et al.
>
> Spindler, S. R., Mote, P. L., Flegal, J. M., & Teter, B. (2013). Influence
> on longevity of blueberry, cinnamon, green and black tea, pomegranate,
> sesame, curcumin, morin, pycnogenol, quercetin, and taxifolin fed
> iso-calorically to long-lived, F1 hybrid mice. *Rejuvenation
> research*, *16*(2),
> 143-151.
>
> Author information:
> (1)Department of Biochemistry, University of California at Riverside,
> California
> 92521, USA. spindler@ucr.edu
>
> Phytonutrients reportedly extend the life span of Caenorhabditis elegans,
> Drosophila, and mice. We tested extracts of blueberry, pomegranate, green and
> black tea, cinnamon, sesame, and French maritime pine bark (Pycnogenol and
> taxifolin), as well as curcumin, morin, and quercetin for their effects on the
> life span of mice. While many of these phytonutrients reportedly
> extend the life
> span of model organisms, we found no significant effect on the life
> span of male
> F1 hybrid mice, even though the dosages used reportedly produce defined
> therapeutic end points in mice. The compounds were fed beginning at 12
> months of
> age. The control and treatment groups were iso-caloric with respect to one
> another. A 40% calorically restricted and other groups not reported here did
> experience life span extension. Body weights were un-changed relative
> to controls
> for all but two supplemented groups, indicating most supplements did not change
> energy absorption or utilization. Tea extracts with morin decreased weight,
> whereas quercetin, taxifolin, and Pycnogenol together increased weight. These
> changes may be due to altered locomotion or fatty acid biosynthesis. Published
> reports of murine life span extension using curcumin or tea components may have
> resulted from induced caloric restriction. Together, our results do not support
> the idea that isolated phytonutrient anti-oxidants and anti-inflammatories are
> potential longevity therapeutics, even though consumption of whole fruits and
> vegetables is associated with enhanced health span and life span.
>
> PMID: 23432089 [PubMed – indexed for MEDLINE]
>
>
> On Sun, Mar 15, 2015 at 8:43 PM, Dr. Harold Katcher
> wrote:
>
> > No offense Edouard but the fact that the quercetin-consuming mice lived
> > 10% shorter lives is helpful information. Of course you’ve got to analyze
> > this in terms of the dose and what the dose equivalent in people would be –
> > but I don’t think that’s a good thing to decrease lifespan. At the least if
> > means there’s a limit beyond which more harm than good is done – like most
> > ‘medicines’. Again, we’re tilting at windmill’s each statistical increase
> > in lifespan in mice may have nothing to do with increasing human lifespan.
> > The most important think I think is to realize the a living thing is not
> > just a collection of genes. Yes, there are something like twenty-something
> > thousand proteins, and then with alternate reading frames and differential
> > splicing we might double that number, but there are hundreds of thousands
> > of enhancer regions, and dozens (at least estimates range into the
> > millions) of histone codons, there is the heirarchical organization of the
> > interphase nucleus influencing gene regulation, There is a four dimensional
> > structure to a life – you are not given a collection of genes – those genes
> > are exposed in a partcular order as development proceeds – you become an
> > embryo, a fetus, a neonate, a baby, a todler – and ending with, late middle
> > age, early old age, middle old age, old old age – death) the entire
> > scenario that you are born with – that you act out throughout your lives.
> > I think the bacterial virus T4 most influenced me – it played out its life
> > like a lighted fuse – transcription starting at the 5′ end of the organism
> > and traveling towards the 3′ end. At the 5′ end are all the “early” genes
> > (early early, middle early and late early) that chew apart the host DNA
> > substitute their own sigma factors to direct the host RNA polymerase to
> > viral DNA- and at the 3′-end is the lysozyme gene whose product will lyse
> > the bacterial cell wall (all of this has been taking place in a bacterium),
> > releasing all the progeny. Now our lives have many more choices – (T4 has
> > none, bacteriophage lambda can choose to be lytic or become a dormant part
> > of the host DNA) – but I think the basic plan is the same – a four
> > dimensional progression. Even when we look at the progression of
> > hemoglobins during development we see the different hemoglobin genes are
> > linearly arrange in the order they appear in the embryo/fetus/newborn.
> > Sincerely,
> > Harold
> >
> >
> >

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About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. http://www.AgingIntervention.org Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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