I have read about the rejuvenated Thymus too so there is definately a rejuvenating effect from old tissue and organs put into a young environment at least for Thymus in mice that is. I know that FOXN1 was one factor responsible for rejuvenating the organ. Just goes to show plasma is worth exploring to see how much it can restore the system.
I am wondering if anyone has heard anything about the Wyss-Coray trials and if he has noticed any significant results yet? He reported regeneration of the Hippocampus in mice so I am hoping similar in the Human trial he is running.
I noticed Alkhest has attracted interest from big pharma Grifols, I imagine they are already looking into ways to emulate the positive factors in blood. Makes me wonder if they are investing that preliminary results might be showing promise.
From: Dr. Harold Katcher To: Gerontology Research Group ; Gerontology Research Group Sent: Sunday, 15 March 2015, 18:14Subject: Re: [GRG] Plasma Factors and aging
So I looked up serial transplantation all the way back to 1940 and couldn’t find anything. I do remember reading about it and I’m usually right about those things, but the following paper gives the case of the involuted, dysfunctional thymus that regained functionality in a young animal and lasted the rest of its life; so that’s two lifespans (which should top the 120 year limit) – Song, Z., Wang J, Guachalla LM, Terszowski G, Rodewald H-R, Ju
Z, Lenhard RK, Rudolf, K.L Alterations of the systemic environment are the
primary cause of impaired B and T lymphopoiesis in telomere-dysfunctional mice.
Blood 2010; 115(8): 1481–9. It’s an amazing paper for various reasons – I’ll attach it if no one minds. Pretty curious that no one has investigated these effects and yet we perform organ transplants all the time? Maybe they were done before the 1940s? I’d bet Caleb (Tuck) Finch would know.