It may depend upon which cell type you are interested in, for example peripheral blood leukocytes, fibroblasts or CNS pyramidal neurons. I had the opportunity to talk with Leonard Hayflick shortly after discovery of the role of telomere shortening in fibroblast proliferative capacity “Hayflick limit”. He seemed to think that telomere shortening played a fundamental role in terminal differentiation. He also told me that fibroblasts that lose their proliferative capacity don’t die, they just become fibrocytes.
On Mon, Mar 16, 2015 at 5:07 PM, Thomas Coote wrote:
IMO the fundamental question that has still not definitively been answered is:
Is telomere erosion causing aging or is it a result of aging?
If anyone can clear up that question then telomere restorative therapies might be the subject of more focus.
On Tuesday, March 17, 2015, steve hill wrote:
Ok so there have been experiments using Plasma in mice which has shown some rejuvenation and there have been experiments using mTERT to rejuvenate telomeres in mice to extend lifespan. However so far to my knowledge no one has attempted a combination of both therapies.
Most of us here would likely agree that increasing life and health span dramatically is likely going to need more than a single magic bullet. So I am wondering how well a combination of regenerative therapies might work.
Would mice with their differing Telomere mechanic be the best animal model? Could we use a knockout mouse with short telomeres to better test this and lengthen them via mTERT plus add young to old plasma to test this?
Could have a control group, an mTERT group, Plasma Group and one with both therapies to see which is better.