Re: [GRG] Combined Therapies mTERT + Plasma

 

Shortening telomeres are known to silence nearby gene expression in cells via TPE which would explain why cells stop expressing youthful genes. However are you suggesting that if the cell is exposed to transcription factors eg, those found in young blood it would rejuvenate the telomere length too?

 

If this was the case that would mean the telomeres would in theory cease silencing youthful genes nearby via TPE and allow adjacent cells to express the genes previously being silenced. In other words a return to youthful function.

 

This would suggest Telomeres act more akin to a time based gene retarder than a conventional clock as some believe. So as they shorten they begin silencing gene expression which then leads to an older environment and the spiral continues downwards as SASP then starts to be transmitted and the environment becomes more unstable.

 

If this is the case then increasing telomere length to reinstate youthful gene expression and clearing out the old milieu could bring about rejuvenation. 

 

The problem I see in using mice is their telomere mechanics are not the same as ours which is why I believe intervention with our telomeres would bring much more impressive results. Now if telomere length can be increased via natural transcription factors in young plasma rather than gene therapy eg, TERT activation via AAV that would be very profund indeed. It would suggest that a course of HPE could considerably regnerate the body.

 

From: Dr. Harold Katcher To: Gerontology Research Group Sent: Tuesday, 17 March 2015, 1:32Subject: Re: [GRG] Combined Therapies mTERT + Plasma

Thomas, 

That’s a really good question and one I tried to answer in my 2013 paper (I don’t publish much). My conclusion based on the work of Lapasset is that if you rejuvenate a cell – using transcription factors to change them (some) to induced pleuripotent cells- not only does their mitochondrial functioning return to normal and they stop producing ROS but their telomeres grow long again (and experiments have shown that the procedures didn’t select for long telomered cells to be induced to pleuripotence. My conclusion is that there’s no mechanism preventing telomerase from lengthening telomeres – other than the body signals not to do so. None of this damage is other than purposeful. My solution is to convince the body that’s its young again, and it will act accordingly (to oversimplify a bit). That shortening telomeres cause many age-related conditions I have no doubt – but I think it’s long known that the strict “end-replication problem’ to explain replicative

 senescence as envisioned by Olivnikov, where each cell division shortens the telomeres isn’t the truth – or at least it isn’t the way it has to be.

Sincerely,

Harold

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About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. http://www.AgingIntervention.org Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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