Re: [GRG] Combined Therapies mTERT + Plasma

Michael,While I agree that telomere attrition is basically a
mechanism for tissue homeostasis – I don’t think you can make man and
mouse equivalent – mice are known to keep their telomere length constant
(up until their extreme old age at least).  Mice that are defective in
this suffer some of the same diseases of aging that men do. I think
after time short-telomere cells become more numerous (statistically
speaking) and these cell basically have three choices – to apoptose, to
senescence (become senescent rather than merely non-cycling), to evade
control and become tumor cells. I think a fourth choice would have to be
be to remain non-cycling but not senescent, but in the inflammatory
environment of the aged body, the cell has little choice but to come
under the control of NF-kB (induced by pro-inflammatory cytokines like
TNF (‘TNF-alpha’ is apparently no longer to be used) and exhibit the
SASP (senescence associated secretory phenomenon), that defines
‘senescent’ cells.)  So I do think that the telomere is one of several
‘clocks’ that the organism uses to remember it is in a post-adult stage
during which it further shuts off the repair and maintenance machinery
(it appears in mice and men that double-strand DNA repair enzymes are
down-regulated at the border between late middle age and early old age).
In mice the disintegration of the genome – the chromosomes falling
apart, with DNA mini-circles becoming more common,  is the normal cause
of death. With us cells containing shorter-than-critical length
telomeres send that information to other cells – distant ones in other
organs, via the bloodstream – and those other cells react accordingly –
exhibiting the DDR (DNA damage response). That causes changes in organs
that cause further aging at the cellular level, which again signals
organs, round and round the toilet bowl until….  It’s complicated, but
is there any part of life that isn’t (our minds are so simple compared
to Nature’s imagination).  I think that telomere shortening contributes
to the diseases of aging – but is there any part of aging that’s not a
disease process intended to harm us?  For the good of the species of
course. So either we ‘suck it up’ (‘keep a stiff upper lip’) or like 
American’s decided in 1776 – to govern ourselves and make our own
decisions about what’s best (in any case Nature will still be calling
the shots). Imagine if we had rational governments that were actually
interested in the benefit of their people – and not backing some
religious/political/personal ideology that accepts all non-members as
destined for Hell or at least an early death- and see life as a
temporary setback on their way to eternal bliss. Life all a test – but
you may never get the results.  Wonder if pigs facing the butcher wonder
if this is a test, the entrance to a new world – but just wind up as
bacon?   Makes me despair sometimes – but perhaps we are delivering what
religion only promises?  In any case – the very idea of real
immortality – liviing billions of billions of years – without end – is
the scariest thought I can think of – like tossing and turning in bed in
a never-ending night. But a thousand years (one already accept by the
Bible as a human lifespan in the ‘old days’) – makes the difference
between interstellar travel and not. Sincerely,Harold


About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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