Walt, here are some research references I can share re: the impact of “Lifestyle Actions,” including Exercise and Stress Management techniques, on telomere length and telomerase activity, which can be quite profound:
— Exercise: “Short-term
running (21 days) up-regulated cardiac telomerase activity to >2-fold of sedentary controls,” [C. Werner,
et. al., J Am Coll Cardiol, 2008]
— “Leukocyte Telomere
Length of older endurance-trained adults was approx. 900bp greater (+12.7%) than
their sedentary peers (P<0.01) and was not significantly different from
young exercise-trained adults,” [T. Larocca, et.al., Mech Ageing Dev. Jan.
— Psychosom Med.2011 Sep; Physical activity
moderates effects of stressor-induced rumination on cortisol reactivity, M
Wolkowitz OM, Epel E.
One. 2010 May 26;The power of exercise: buffering the effect of chronic
stress on telomere length, Blackburn E, Epel E.
Cherkas and J.L. Hunkin et al., The association between physical
activity in leisure time and leukocyte telomere length, Arch. Intern.
Ageing Dev. 2010 Jan 11. Leukocyte telomere length is preserved with
aging in endurance exercise-trained adults and related to maximal aerobic
capacity. Larocca TJ
–J Appl Physiol, March 22, 2007; High-intensity exercise elicits the
mobilization of senescent T lymphocytes into the peripheral blood compartment
in human subjects, Keith Guy
— Epel ES, Blackburn EH, Lin J, Accelerated telomere shortening in
response to life stress. Proceedings of the National Academy of
H, Accelerated Telomere Erosion Is Associated with a Declining Immune
Function of Caregivers of Alzheimer's Disease Patients. J Immunol. 2007
ES, Cawthon R, et al. Cell aging in
relation to stress arousal and cardiovascular disease risk factors. Psychoneuroendocrinology.
— Choi J, Fauce SR, Effros RB. Reduced
telomerase activity in human T lymphocytes exposed to cortisol. Brain,
Behavior, and Immunity. 2008
O’Donovan and J. Lin et al., Pessimism correlates with leukocyte
telomere shortness and elevated interleukin-6 in post-menopausal women, Brain
Behav. Immun. (2009),
— Ann N
Y Acad Sci. 2009 Aug; Can meditation slow rate of cellular aging?
Cognitive stress, mindfulness, and telomeres. Epel E, Blackburn E
— E.S. Epel et al., Intensive
meditation training, immune cell telomerase activity, and psychological
mediators, Psychoneuroendocrinology (2011),
— Int J
Geriatr Psychiatry, 2011. A pilot study of yogic meditation for family
dementia caregivers with depressive symptoms: effects on mental health,
cognition, and telomerase activity. Epel E, Blackburn E: +43% Increase in Telomerase Activity for Yogic
Meditation group vs. Control.
Telomere Biosciences, LLC.
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