Re: [GRG] are short telomeres a cause or a result of aging?

Walt,  here are some research references I can share re: the impact of “Lifestyle Actions,” including Exercise and Stress Management techniques, on telomere length and telomerase activity, which can be quite profound:  


— Exercise:  “Short-term
running (21 days) up-regulated cardiac telomerase activity to >2-fold of sedentary controls,” [C. Werner,
et. al., J Am Coll Cardiol, 2008]


  — “Leukocyte Telomere
Length of older endurance-trained adults was approx. 900bp greater (+12.7%) than
their sedentary peers (P<0.01) and was not significantly different from
young exercise-trained adults,” [T. Larocca,, Mech Ageing Dev. Jan.




— Psychosom Med.2011 Sep; Physical activity
moderates effects of stressor-induced rumination on cortisol reactivity, M
Wolkowitz OM, Epel E.

— PLoS
One. 2010 May 26;The power of exercise: buffering the effect of chronic
stress on telomere length, Blackburn E, Epel E.

— L.F
Cherkas and J.L. Hunkin et al., The association between physical
activity in leisure time and leukocyte telomere length, Arch. Intern.
Med. 2008

— Mech
Ageing Dev. 2010 Jan 11. Leukocyte telomere length is preserved with
aging in endurance exercise-trained adults and related to maximal aerobic
capacity. Larocca TJ

–J Appl Physiol, March 22, 2007; High-intensity exercise elicits the
mobilization of senescent T lymphocytes into the peripheral blood compartment
in human subjects,  Keith Guy


Stress Management:

—  Epel ES, Blackburn EH, Lin J,  Accelerated telomere shortening in
response to life stress. Proceedings of the National Academy of
Sciences. 2004;

— Nguyen
H, Accelerated Telomere Erosion Is Associated with a Declining Immune
Function of Caregivers of Alzheimer's Disease Patients. J Immunol. 2007

— Epel
ES,  Cawthon R, et al. Cell aging in
relation to stress arousal and cardiovascular disease risk factors. Psychoneuroendocrinology.

—  Choi J, Fauce SR, Effros RB. Reduced
telomerase activity in human T lymphocytes exposed to cortisol. Brain,
Behavior, and Immunity. 2008

— A.
O’Donovan and J. Lin et al., Pessimism correlates with leukocyte
telomere shortness and elevated interleukin-6 in post-menopausal women, Brain
Behav. Immun. (2009),

— Ann N
Y Acad Sci. 2009 Aug; Can meditation slow rate of cellular aging?
Cognitive stress, mindfulness, and telomeres. Epel E, Blackburn E

—  E.S. Epel et al., Intensive
meditation training, immune cell telomerase activity, and psychological
mediators, Psychoneuroendocrinology (2011),

— Int J
Geriatr Psychiatry, 2011. A pilot study of yogic meditation for family
dementia caregivers with depressive symptoms: effects on mental health,
cognition, and telomerase activity. Epel E, Blackburn E: +43%  Increase in Telomerase Activity for Yogic
Meditation group vs. Control.


David Cross


Telomere Biosciences, LLC.

David B. Cross

Founder & President

Cell: 917.370.7456

TELO-100 with T-Activator 150

TELO-20 for Dogs

Longer Telomeres for a Longer Healthspan TM 




About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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