I’m sure everyone knows, but Steve Horvath is the guy who analyzed DNA methylation patterns across many tissue types and found that the progression of methylation patterns allows you to ‘guess’ the age of the participant to within five years. The next question to ask is if those changing methylation patterns are a product of the chronological age of the person (the work was on human DNA methylation) or of the ‘physiological age’ and can predict mortality. I think that Dr. Horvath’s presentation will help to answer that question. I would like to see if Dr. Horvath might possibly cooperate on the ‘plasma exchange’ experiments – DNA methylation patterns seem to be about the best aging biomarkers. The other big question is why cancer increases exponentially with age: there are several guesses; the immune system is deficient, there is genetic dysregulation, there are chromatin abnormalities and abnormalities in epigenetics, in splicing etc. It would be really interesting to hear what Steve Horvath has to tell us.