Re: [GRG] Discovery can help stop emergence of age-related neurodegenerative diseases

Dear Sheldon

Interesting thought though I am unsure as I am not an expert in Telomeres.

It is possible blood factors may restore them along with other tissue though to my knowledge no one has measured them in combination with plasma therapy so hard to say. It would be nice if they did but until it is tested it is probably being very optimistic.

We certainly have easy access to the technology to test it though.


From: Sheldon Ball To: steve hill Sent: Tuesday, 24 March 2015, 18:07Subject: Re: [GRG] Discovery can help stop emergence of age-related neurodegenerative diseases

Hi Steve,
Nice train of thought. I wonder about the relative role of post-mitotic versus proliferating cells in regulating human aging and how telomere length would impact on post-mitotic cells over time.

On Tue, Mar 24, 2015 at 10:51 AM, steve hill wrote:

Dear Sheldon and all,

Plasma therapy could get around that issue as the factors are in the blood naturally and I imagine they should pass through the BBB to rejuvenate the Hypothalamus rather than using manufactured small molecules that may be too large to pass through? Though the experiment mentioned in the initial post focused on a small slice of aging function it does show that intervention is possible which is hopeful. 

Parabiosis and plasma exchange experiments in the past have certainly hinted at this level of rejuvenation. In 2002 Rando et al showed the Liver regenerated in mice after only 5 weeks of exposure to younger blood so clearly there is some restoration to that part of the Endocrine system. I have also read about a Thymus being regenerated to youthful function via factors too, so this shows at least some of the system does rejuvenate when exposed to younger factors.

There are indications of improved cognitive ability too which indicates factors can penetrate the BBB to rejuvenate the brain. 

Harold Katcher published an interesting article about the power of blood factors and is why I believe they hold the key to Epigenetic reprogramming of the aging system.

I share Dr Katcher’s belief that circulating factors could effect the endocrine system and effectively reprogram it by changing the methylation patterns so the glands begin to secrete more youthful factors. I think with sufficient exposure to a younger milleau we may see the system reset to a younger phenotype. The Hypothalamus, spleen, Thyroid, thymus, liver etc… all part of the Endocrine system could after enough exposure stabilize the system and remember how to be young again.

However I am not a Scientist though I do wonder what causes the whole system to destabilize in the first place and I still suspect Telomeres play a part. I would be interested in seeing if circulating factors in any way change telomere length but I guess we wont know until we test it. 



sheldon Ball

To: steve hill ; Gerontology Research Group Sent: Tuesday, 24 March 2015, 16:35Subject: Re: [GRG] Discovery can help stop emergence of age-related neurodegenerative diseases

Hi Steve,
The combination of a focus on the central nervous system, especially the hypothalamus and circulating plasma factors seems a more promising approach than telomere length in myoblasts in the study of human aging. I look forward to hearing more of your thoughts on this approach.

At least one of the problems may be that the hypothalamus is hard to get to (in a living person). This should not alter your reasoning process.


On Tue, Mar 24, 2015 at 3:48 AM, steve hill wrote:

Fascinating and further evidence for intervention via Epigenetic reprogramming of the system.


Paraboisis has hinted at this with rejuvenation of cognitive function in mice, could circulating youthful blood factors possibly restore some level of youthful function to the hypothalamus and its endocrines?


Surely if the Hypothalamus is the central controller of aging/metabolism would it not make the ideal target for intervention?

From: “Steven Charlap, MD” To: Gerontology Research Group Sent: Tuesday, 24 March 2015, 3:15Subject: [GRG] Discovery can help stop emergence of age-related neurodegenerative diseases


About Johnny Adams

My full-time commitment is to slow and ultimately reverse biological aging and age related decline for more years of healthy living. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Aging Intervention Foundation (dba for Carl I. Bourhenne Medical Research Foundation), an IRS approved 501(c)(3) nonprofit. Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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