Targeting/Taming Aging With Metformin (TAME) Study

NOTE: If you are interested in participating in a clinical trial for a therapy to slow and ultimately reverse age related decline for more healthy years of life, contact me at (949) 922-9786 or email JAdams -at-

Targeting/Taming Aging With Metformin (TAME) Study

Some high points of the article link below:

  • Nir Barzilai, M.D., is the Director, Institute for Aging Research, Einstein College of Medicine and Scientific Co-Director of The American Federation for Aging Research.
  • The main reason of the TAME study is to convince the Food and Drug Administration (FDA) to approve aging as an indication, and thus a target for future and even better medications.
  • Barzilai and team hypothesize that delaying aging is the only effective way to delay age-related diseases and compress morbidity.
  • Metformin is an FDA-approved drug and first-line drug of choice for prevention and treatment of type 2 diabetes (T2DM).
  • Metformin extends the lifespan and healthspan in animals, and has shown positive effects in humans.  There’s an association of metformin with decreased risk of cancer, as well as decreased cancer mortality
  • TAME is a novel study that will recruit elderly subjects and, in a double-blind, placebo-control study, will test if metformin can delay the onset of multi-morbidities including cancer, CVD, T2DM, cognitive decline, and mortality.
  • A number of experts are involved in the project, like Dr. S. Jay Olshansky and Dr. Jim Kirkland among others.
  • Barzilai said “I was raised on the belief that it is possible to change the world (or part of it). Many have said it before and failed. But it doesn’t matter, you start again with a better plan. The difference today is that by creating collaborations, opportunities, and friendships with many others we have more than a village to succeed.


About Johnny Adams

My full-time commitment is to slow and ultimately reverse biological aging and age related decline for more years of healthy living. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Aging Intervention Foundation (dba for Carl I. Bourhenne Medical Research Foundation), an IRS approved 501(c)(3) nonprofit. Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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5 Responses to Targeting/Taming Aging With Metformin (TAME) Study

  1. George McCaffrey says:

    I am a healthy 66 year old male, retired Naval Officer. I am interested in the TAME Program. I live just outside Pittsburgh, Pa. I want to volunteer to participate in the human testing phase.

  2. Stephanie Hansen says:

    How does one apply to be in the study?

  3. Johnny Adams says:

    Our foundation isn’t actually doing the metformin study. I just talked with a representative from the American Federation for Aging Research and was told they are now setting up sites to do the research and not accepting enrollees now.

  4. F.Tyrell. says:

    I am 71 years old and interested in being a volunteer in the testing protocol for ‘tame’.

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