Quantification of biological aging in young adults

Quantification of biological aging in young adults

http://www.pnas.org/content/112/30/E4104.full

Biomarkers measuring results
http://www.pnas.org/content/suppl/2015/07/01/1506264112.DCSupplemental/pnas.1506264112.sapp.pdf

Numerous blood measures: starts at “Pace of Aging”
Glycated hemoglobin, forced expiratory volume in one second (FEV1) and others
Physical Limitations
Cognitive Testing
Retinal Imaging
Self Rated Health
Facial Aging

Young People Age at Different Rates
BioTechniques
08/31/2015
Kristie Nybo, PhD

A newly developed method for measuring aging during youth confirmed that some people age quicker than others.

Logically, it seems that one year in time should add one year of wear and tear to your body. But some years seem harder on us than others and some people maintain their baby faces long after their same-age peers develop wrinkles. Now in the journal Proceedings of the National Academy of Sciences, researchers present a new method to measure the rate of aging in young people and used it to confirm the suspicion that people age at different rates.

To develop the new approach, Israel’s team turned to the Dunedin Study, a collection of 1037 individuals monitored from birth until age 38 for 18 biomarkers established as risk factors for chronic disease. The team assessed indicators of the health of the cardiovascular, metabolic, and immune systems, as well as kidney, liver, and lung functions, dental health, and DNA features such as telomere length.

Although none of the study participants showed evidence of age-related disease, test results indicated that the 38 year old study participants ranged from 28 to 61 years old biologically. By using measurements from ages 26, 32, and 38, the team quantified each study participant’s rate of physiological deterioration and found that some participants showed nearly 3 years of physiological change per chronological year, while others showed almost no change at all.

The researchers found that biomarker evidence of advanced biological age correlated with poor performance on balance and motor tests, reduced muscle strength, and poor cognitive functioning. These individuals also looked older to undergraduate students estimating the age of individuals in photos.

“This research shows that age-related decline is already happening in young adults who are decades away from developing age-related diseases, and that we can measure it,” Israel said.

Interestingly, three study participants’ biomarkers indicated that they were growing healthier or younger during their 30s.

“Above all, measures of aging in young humans allow for testing the effectiveness of antiaging therapies (e.g., caloric restriction) without waiting for participants to complete their lifespans.”

http://www.biotechniques.com/news/biotechniquesNews/biotechniques-360179.html?utm_source=BioTechniques+Newsletters+%26+e-Alerts&utm_campaign=bc6850d06f-weekly&utm_medium=email&utm_term=0_5f518744d7-bc6850d06f-87353018#.VetKXM7OTII

 Reference

Belsky DW, Caspi A, Houts R, Cohen HJ, Corcoran DL, Danese A, Harrington H, Israel S, Levine ME, Schaefer JD, Sugden K, Williams B, Yashin AI, Poulton R, Moffitt TE. Quantification of biological aging in young adults. Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):E4104-10.

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About Johnny Adams

My full-time commitment is to slow and ultimately reverse age related functional decline to increase healthy years of life. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Carl I. Bourhenne Medical Research Foundation (Aging Intervention Foundation), an IRS approved 501(c)(3) nonprofit. http://www.AgingIntervention.org Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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