Just a few highlights, best to read it all
– G-quadruplexes are secondary semi-stable folded structures found in our DNA and RNA which tend to assemble around guanine-rich sequences in the presence of cation molecules like potassium.
– The article and images show how G-complexes make DNA look a lot more complicated than “prevailing dogma” (simple guanine/cytosine base pairs) shows.
– G-quadruplexes are an alternative way that DNA and RNA can fold – and adopt a variety of geometric configurations depending on where they are found.
– They’re very relevant to many critical biological processes like gene regulation, expression of telomerase and telomere maintenance, understanding of growth/oncogenes like C-myc, understanding of organismic development, comprehension of certain enigmatic diseases like ALS and possible new cancer treatments.
– Many critical aging-related processes like the telomere/telomerase story can’t be fully told without considering G-quadruplexes.
– G-quadraplexes are only one of several types of quadraplex structures
– Article continues in detail. It’s a recommended read.