Do you ever buy things?

Dear GRG Member,

Do you ever buy things?

Will you support the creation of aging solutions by buying them on Amazon?

It won’t cost you anything!

A FEW items you can buy on Amazon —
Books, Appliances, Apps, Games, Automotive, Computers, Health products,
Office supplies, Tools and lots more.

Search Amazon for whatever you need.

GO TO THIS PAGE FIRST, then click the link to Amazon.
www.grg.org/grg/amazon

Johnny

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Scientists successfully edit human immune-system T cells

Dear GRG Member,

An advance toward aging interventions.

Scientists successfully edit human immune-system T cells

  • The CRISPR/Cas9 system makes it possible to easily and inexpensively edit genetic information in virtually any organism.
  • T cells, which circulate in the blood, are an obvious candidate for medical applications of the technology, as these cells not only stand at the center of many disease processes, but could be easily gathered from patients, edited with CRISPR/Cas9, then returned to the body to exert therapeutic effects.
  • A protein on the T-cell surface called CXCR4 was disabled. CXCR4 can be exploited by HIV.
  • The group successfully shut down PD-1, a protein that has attracted intense interest in the burgeoning field of cancer immunotherapy, as scientists have shown that using drugs to block PD-1 coaxes T cells to attack tumors.
  • Alexander Marson, PhD, a UCSF Sandler Fellow says it’s difficult, and the group is driving as hard as they can toward applications.
  • The new work was done under the auspices of the Innovative Genomics Initiative (IGI), a joint UC Berkeley-UCSF program co-directed by Berkeley’s Jennifer Doudna, PhD, and Jonathan Weissman PhD.
  • More details about the program, IGI, supporters and UCSF follow.

I heard about this first from Kurzweil AI

http://www.kurzweilai.net/scientists-successfully-edit-human-immune-system-t-cells

https://www.ucsf.edu/news/2015/07/131146/crispr-advance-scientists-successfully-edit-human-t-cells

Johnny

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Ancestry.com teams with Calico

Dear GRG Member,

Understanding aging: Ancestry.com teams with Google’s Calico
By Meghana Keshavan
MedCity News

Highlights:
– Ancestry.com teaming with Calico to study the human heredity
aspects of lifespan.
– Ancestry’s is entering healthcare – building out a new arm,
AncestryHealth, whose first offering is a tool to track hereditary disease.
– The two companies will work together to examine the role of
genetics, and how they influence lifespan in those families, particularly,
that have unusual longevity.
– They’ll try to find hereditary factors underlying longevity, and
find genes responsible
– Ancestry.com is for sale

Entire article:
http://ift.tt/1Ki6C6g

*** CLICK HERE to Support — and Benefit From — Aging Solutions ***

CLICK HERE for the Main Foundation Web Site: Carl I. Bourhenne Medical Research Foundation / Aging Intervention Foundation

About Me: Johnny Adams

Call Johnny at (650) 265-4969 or (949) 922-9786 cell

Email: JAdams – at – AgingIntervention .org

Posted in aging, anti-aging, antiaging, gerontology, healthspan, increase healthy years, life extension, longevity, reverse aging, slow aging | Tagged , , , , , , , , , | Leave a comment

2 of 2 Quantification of biological aging in young adults / Measuring the pace of biological aging

How Quickly Are You Growing Old?

Measuring the pace of biological aging in young people could someday help prevent age-related diseases

Wall Street Journal
Samathi Reddy
July 13, 2013

Highlights

  • Daniel Belsky is first author and assistant professor of medicine at Duke University School of Medicine
  • Article starts with background.
  • The aim of the research is to be able eventually to identify signs of premature aging before it becomes evident years or decades later in chronic diseases such as cardiovascular disease, diabetes or kidney and lung impairment.
  • “Intervention to reverse or delay the march toward age-related diseases must be scheduled while people are still young,” according to the study, published online last week in the Proceedings of the National Academy of Sciences.
  • The researchers relied on 18 separate biomarkers to measure the pace of biological aging
  • Study examined the pace of aging over time
  • “pace of biological aging” is defined as the declining integrity of multiple organ systems.
  • Belsky said the research team also hopes to investigate differences in how fast people age by looking at genetics, lifelong environmental factors and lifestyle behaviors.
  • Quotes from Nir Barzilai, James Kirkland and Stephen Kritchevsky
  • “The primary message is that what happens to us at the end of life has its roots early in life,” said Dr. Kritchevsky of the new study in the Proceedings of the National Academy of Sciences. “Investments in your health in middle age will have payoffs in old age.”

From article:
Biomarkers2

Article
http://www.wsj.com/articles/how-quickly-are-you-growing-old-1436808166

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1 of 2 Quantification of biological aging in young adults / Measuring the pace of biological aging

Study published in PNAS.

Quantification of biological aging in young adults

Highlights

  • Significance
    • The global population is aging, driving up age-related disease morbidity. Antiaging interventions are needed to reduce the burden of disease and protect population productivity.
    • Young people are the most attractive targets for therapies to extend healthspan (because it is still possible to prevent disease in the young).
    • However, there is skepticism about whether aging processes can be detected in young adults who do not yet have chronic diseases. Our findings indicate that aging processes can be quantified in people still young enough for prevention of age-related disease, opening a new door for antiaging therapies. The science of healthspan extension may be focused on the wrong end of the lifespan; rather than only studying old humans, geroscience should also study the young.

Study:
http://www.pnas.org/content/early/2015/07/01/1506264112.abstract

Authors
http://www.pnas.org/content/early/2015/07/01/1506264112.abstract?tab=author-info

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Scientists discover key driver of human aging — Findings on premature aging syndrome could lead to way of slowing or reversing aging process

Salk Institute for Biological Studies
News Release
Scientists discover key driver of human aging
Findings on premature aging syndrome could lead to way of slowing or reversing aging process

Some highlights:

  • Salk team was lead by Juan Carlos Izpisua Belmonte
  • Ties the aging process to the deterioration of tightly packaged bundles of cellular DNA
  • Werner syndrome causes people to age faster than normal
  • Genetic mutations underlying Werner syndrome resulted in the deterioration of bundles of DNA known as heterochromatin
  • Belmonte says “This has implications beyond Werner syndrome, as it identifies a central mechanism of aging–heterochromatin disorganization–which has been shown to be reversible.”
  • Discovery made possible through a combination of cutting-edge stem cell and gene-editing technologies
  • Werner syndrome is caused by a mutation to the RecQ helicase-like gene (WRN) which generates the WRN protein.
    • Normal form of the protein is an enzyme that maintains DNA structure and integrity.
    • Mutated Werner syndrome protein disrupts replication and repair of DNA and the expression of genes, which was thought to cause premature aging.
  • Salk scientists sought to determine precisely how the mutated WRN protein causes so much cellular mayhem
    • They created an unprecedented cellular model of Werner syndrome by using a cutting-edge gene-editing technology to delete WRN gene in human stem cells
    • Resulting cells mimicked the genetic mutation seen in actual Werner syndrome patients, so the cells began to age more rapidly than normal.
    • Deletion of the WRN gene also led to disruptions to the structure of heterochromatin, the tightly packed DNA found in a cell’s nucleus.
    • So the WRN protein helps maintain heterochromatin
  • Researchers showed that the protein interacts directly with molecular structures known to stabilize heterochromatin–revealing a kind of smoking gun that, for the first time, directly links mutated WRN protein to heterochromatin destabilization.
  • Izpisua Belmonte added that more extensive studies will be needed, including how it interacts with other cellular processes implicated in aging, such as telomere shortening.

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Final point for aging solutions:

  • Belmonte team is developing epigenetic editing technologies to reverse epigenetic alterations with a role in human aging and disease.

~~~~~~~~~~~~~~~~~~

Article:
http://www.salk.edu/news/pressrelease_details.php?press_id=2080

Johnny


GRG Member Harold Katcher sent the following useful information:

That disorganization of heterochromatin is a downstream process. Think that the helicase is either down-regulated with age or miRNAs against it are up-regulated or both or some other life-stage-dependent mechanism prevents chromatin repair and remodeling.  So in the case of Werner’s syndrome, the helicase gene is constitutionally lost or impaired at age zero, in non-Werner’s folks (us), it becomes reduced in effect with age, thus allowing a longer lifespan. But it is one of many aging clocks I believe, the telomeres are another, mitochondrial dysfunction….

So the question is, since we know that genes are not randomly activate/inactivated at different life-stages  (as opposed to the ‘wear and tear’ers who believe that randomly inactivated essential genes for repair and maintenance  produces aging  (while no other genes are apparently ‘randomly’ inactivated), that position sounds so dubious as to make me feel embarrassed for the majority of scientists in aging research), the question is what inactivated those repair and maintenance genes?  Is it a cell-intrinsic process or is it signalling from body to cell? I’d bet on the latter.

Sincerely,
Harold Katcher


*** CLICK HERE to Support — and Benefit From — Aging Solutions ***

CLICK HERE for the Main Foundation Web Site: Carl I. Bourhenne Medical Research Foundation / Aging Intervention Foundation

About Me: Johnny Adams

Call Johnny at (650) 265-4969 or (949) 922-9786 cell

Email: JAdams – at – AgingIntervention .org

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Tony Wyss-Coray video Rejuvenating Old Brains With Young Blood

Tony Wyss-Coray video of presentation at the World Economic Forum in Davos, Switzerland.

Rejuvenating Old Brains With Young Blood

Key points:

  • Background, aging population, burden of aging, loss of cognitive function.
  • Mouse experiments — young blood to old mouse seems to rejuvenate. Old mouse does better on spatial memory test.
  • Brain functions better in a number of learning and memory tests, makes more neurons, less inflammation, neurons connect better.
  • There are messengers in blood — hormones or growth factors.
  • Young and old blood very different.
  • Young blood — had many factors involved in repair and maintenance of tissues.
  • Old blood — factors involved in inflammation
  • Most of the beneficial effects are in the soluble fraction, also called plasma.
  • Isolate the factors, produce them synthetically for use as potential drugs to rejuvenate tissues and potentially help cognitive deficits and other conditions.

Does it work in humans? Alkahest is testing it.

To Watch Video:
https://agenda.weforum.org/2015/04/video-can-we-rejuvenate-the-brain

*** CLICK HERE to Support — and Benefit From — Aging Solutions ***

CLICK HERE for the Main Foundation Web Site: Carl I. Bourhenne Medical Research Foundation / Aging Intervention Foundation

About Me: Johnny Adams

Call Johnny at (650) 265-4969 or (949) 922-9786 cell

Email: JAdams – at – AgingIntervention .org

Posted in aging, anti-aging, antiaging, gerontology, healthspan, increase healthy years, life extension, longevity, reverse aging, slow aging | Tagged , , , , , , , , , | Leave a comment