AGINGSCIENCES™ – Anti-Aging Firewalls™ has posted a new item, ‘G-qaudruplexes’

Just a few highlights, best to read it all

– G-quadruplexes are secondary semi-stable folded structures found in our DNA and RNA which tend to assemble around guanine-rich sequences in the presence of cation molecules like potassium.

– The article and images show how G-complexes make DNA look a lot more complicated than “prevailing dogma” (simple guanine/cytosine base pairs) shows.

– G-quadruplexes are an alternative way that DNA and RNA can fold – and adopt a variety of geometric configurations depending on where they are found.

– They’re very relevant to many critical biological processes like gene regulation, expression of telomerase and telomere maintenance, understanding of growth/oncogenes like C-myc, understanding of organismic development, comprehension of certain enigmatic diseases like ALS and possible new cancer treatments.

– Many critical aging-related processes like the telomere/telomerase story can’t be fully told without considering G-quadruplexes.

– G-quadraplexes are only one of several types of quadraplex structures

– Article continues in detail. It’s a recommended read.

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Aging 2.0 group

Dear GRG Member,

Aging 2.0 about page says
Aging2.0® is a global innovation platform for aging and senior care. It is on a mission to accelerate innovation to improve the lives of older adults around the world. (continues)

Looks like a useful group. You can sign up for their newsletter on main page

Upcoming expo Nov 19-20

Events have product presentations and networking. Leadership team are key members of sister group Generator Ventures. Good to harness free enterprise to advance creation of aging solutions.

They have “Pitch Events”. Look for others
#30in30in30 is an initiative supported by Aging2.0 to encourage local communities around the world to host pitch events for new innovative products and services that stand to improve the lives of older adults. We are taking part by hosting one of 30 Pitch Events in 30 cities around the world in 30 days.


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Quantification of biological aging in young adults

Quantification of biological aging in young adults

Biomarkers measuring results

Numerous blood measures: starts at “Pace of Aging”
Glycated hemoglobin, forced expiratory volume in one second (FEV1) and others
Physical Limitations
Cognitive Testing
Retinal Imaging
Self Rated Health
Facial Aging

Young People Age at Different Rates
Kristie Nybo, PhD

A newly developed method for measuring aging during youth confirmed that some people age quicker than others.

Logically, it seems that one year in time should add one year of wear and tear to your body. But some years seem harder on us than others and some people maintain their baby faces long after their same-age peers develop wrinkles. Now in the journal Proceedings of the National Academy of Sciences, researchers present a new method to measure the rate of aging in young people and used it to confirm the suspicion that people age at different rates.

To develop the new approach, Israel’s team turned to the Dunedin Study, a collection of 1037 individuals monitored from birth until age 38 for 18 biomarkers established as risk factors for chronic disease. The team assessed indicators of the health of the cardiovascular, metabolic, and immune systems, as well as kidney, liver, and lung functions, dental health, and DNA features such as telomere length.

Although none of the study participants showed evidence of age-related disease, test results indicated that the 38 year old study participants ranged from 28 to 61 years old biologically. By using measurements from ages 26, 32, and 38, the team quantified each study participant’s rate of physiological deterioration and found that some participants showed nearly 3 years of physiological change per chronological year, while others showed almost no change at all.

The researchers found that biomarker evidence of advanced biological age correlated with poor performance on balance and motor tests, reduced muscle strength, and poor cognitive functioning. These individuals also looked older to undergraduate students estimating the age of individuals in photos.

“This research shows that age-related decline is already happening in young adults who are decades away from developing age-related diseases, and that we can measure it,” Israel said.

Interestingly, three study participants’ biomarkers indicated that they were growing healthier or younger during their 30s.

“Above all, measures of aging in young humans allow for testing the effectiveness of antiaging therapies (e.g., caloric restriction) without waiting for participants to complete their lifespans.”


Belsky DW, Caspi A, Houts R, Cohen HJ, Corcoran DL, Danese A, Harrington H, Israel S, Levine ME, Schaefer JD, Sugden K, Williams B, Yashin AI, Poulton R, Moffitt TE. Quantification of biological aging in young adults. Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):E4104-10.

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NIA advisory: Can We Prevent Aging?

NIA advisory: Can We Prevent Aging?

Excerpt from National Institute of Aging article — link is below:

The National Institute on Aging (NIA) investigates ways to support healthy aging and prevent or delay the onset of age-related disease and decline. We have already gained important insights, and what we learn from ongoing and future studies may not only help to increase longevity, but may also promote what is known as “active life expectancy”—the time in late life free of disability. We already know, for example, that healthy eating and exercise and physical activity help promote healthy aging. Are there other interventions that can help? NIA-supported and other studies are taking a look at the possible benefits and risks of a number of approaches, including antioxidants, calorie restriction, and hormone supplements. This tip sheet provides an overview of what we know about these interventions and the research needed to learn more. Until we have a better understanding, it is a good idea to be skeptical of claims that any supplements can solve your age-related problems.

Calorie restriction
How Hormones Work
Hormone Therapy
Some Dangers of Hormone Therapy and “Anti-Aging” Supplements
Human Growth Hormone
Hormones in Women
Many Questions, Seeking Answers

Article on the NIA web site:

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21st Century Cures Act

The 21st Century Cures Act was recently approved by the House 51-0. Next Stop: U.S. Senate

This is a major step in advancing the translation of basic science to clinical applications, with implications for aging R&D.

Selections from the web page:

If we want to save more lives and keep this country the leader in medical innovation, we have to make sure there’s not a major gap between the science of cures and the way we regulate these therapies.

. . . for the first time ever, we in Congress have taken a comprehensive look at what steps we can take to accelerate the pace of cures in America. We have looked at the full arc of this process – from the discovery of clues in basic science, to streamlining the drug and device development process, to unleashing the power of digital medicine and social media at the treatment delivery phase.

Connect with Us

The committee is seeking input on this bold new initiative from a wide variety of interested stakeholders.

Engage on social media by liking us on Facebook, Following us on Twitter, and using the hashtags #Path2Cures and #Cures2015.

Email the committee using the email address

21st Century Cures is a truly collaborative effort. Please be advised that submissions sent to will be made publicly available on as part of the effort to encourage continued discussion about opportunities and ideas to accelerate the pace of cures. We thank you for participating.

Fast paced video:

Read the full announcement.
Newsletter subscription is not required.


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Do you ever buy things?

Dear GRG Member,

Do you ever buy things?

Will you support the creation of aging solutions by buying them on Amazon?

It won’t cost you anything!

A FEW items you can buy on Amazon —
Books, Appliances, Apps, Games, Automotive, Computers, Health products,
Office supplies, Tools and lots more.

Search Amazon for whatever you need.

GO TO THIS PAGE FIRST, then click the link to Amazon.


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Scientists successfully edit human immune-system T cells

Dear GRG Member,

An advance toward aging interventions.

Scientists successfully edit human immune-system T cells

  • The CRISPR/Cas9 system makes it possible to easily and inexpensively edit genetic information in virtually any organism.
  • T cells, which circulate in the blood, are an obvious candidate for medical applications of the technology, as these cells not only stand at the center of many disease processes, but could be easily gathered from patients, edited with CRISPR/Cas9, then returned to the body to exert therapeutic effects.
  • A protein on the T-cell surface called CXCR4 was disabled. CXCR4 can be exploited by HIV.
  • The group successfully shut down PD-1, a protein that has attracted intense interest in the burgeoning field of cancer immunotherapy, as scientists have shown that using drugs to block PD-1 coaxes T cells to attack tumors.
  • Alexander Marson, PhD, a UCSF Sandler Fellow says it’s difficult, and the group is driving as hard as they can toward applications.
  • The new work was done under the auspices of the Innovative Genomics Initiative (IGI), a joint UC Berkeley-UCSF program co-directed by Berkeley’s Jennifer Doudna, PhD, and Jonathan Weissman PhD.
  • More details about the program, IGI, supporters and UCSF follow.

I heard about this first from Kurzweil AI


Posted in Uncategorized | Leave a comment teams with Calico

Dear GRG Member,

Understanding aging: teams with Google’s Calico
By Meghana Keshavan
MedCity News

– teaming with Calico to study the human heredity
aspects of lifespan.
– Ancestry’s is entering healthcare – building out a new arm,
AncestryHealth, whose first offering is a tool to track hereditary disease.
– The two companies will work together to examine the role of
genetics, and how they influence lifespan in those families, particularly,
that have unusual longevity.
– They’ll try to find hereditary factors underlying longevity, and
find genes responsible
– is for sale

Entire article:

*** CLICK HERE to Support — and Benefit From — Aging Solutions ***

CLICK HERE for the Main Foundation Web Site: Carl I. Bourhenne Medical Research Foundation / Aging Intervention Foundation

About Me: Johnny Adams

Call Johnny at (650) 265-4969 or (949) 922-9786 cell

Email: JAdams – at – AgingIntervention .org

Posted in aging, anti-aging, antiaging, gerontology, healthspan, increase healthy years, life extension, longevity, reverse aging, slow aging | Tagged , , , , , , , , , | Leave a comment

2 of 2 Quantification of biological aging in young adults / Measuring the pace of biological aging

How Quickly Are You Growing Old?

Measuring the pace of biological aging in young people could someday help prevent age-related diseases

Wall Street Journal
Samathi Reddy
July 13, 2013


  • Daniel Belsky is first author and assistant professor of medicine at Duke University School of Medicine
  • Article starts with background.
  • The aim of the research is to be able eventually to identify signs of premature aging before it becomes evident years or decades later in chronic diseases such as cardiovascular disease, diabetes or kidney and lung impairment.
  • “Intervention to reverse or delay the march toward age-related diseases must be scheduled while people are still young,” according to the study, published online last week in the Proceedings of the National Academy of Sciences.
  • The researchers relied on 18 separate biomarkers to measure the pace of biological aging
  • Study examined the pace of aging over time
  • “pace of biological aging” is defined as the declining integrity of multiple organ systems.
  • Belsky said the research team also hopes to investigate differences in how fast people age by looking at genetics, lifelong environmental factors and lifestyle behaviors.
  • Quotes from Nir Barzilai, James Kirkland and Stephen Kritchevsky
  • “The primary message is that what happens to us at the end of life has its roots early in life,” said Dr. Kritchevsky of the new study in the Proceedings of the National Academy of Sciences. “Investments in your health in middle age will have payoffs in old age.”

From article:


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1 of 2 Quantification of biological aging in young adults / Measuring the pace of biological aging

Study published in PNAS.

Quantification of biological aging in young adults


  • Significance
    • The global population is aging, driving up age-related disease morbidity. Antiaging interventions are needed to reduce the burden of disease and protect population productivity.
    • Young people are the most attractive targets for therapies to extend healthspan (because it is still possible to prevent disease in the young).
    • However, there is skepticism about whether aging processes can be detected in young adults who do not yet have chronic diseases. Our findings indicate that aging processes can be quantified in people still young enough for prevention of age-related disease, opening a new door for antiaging therapies. The science of healthspan extension may be focused on the wrong end of the lifespan; rather than only studying old humans, geroscience should also study the young.



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