Dear Sheldon and all,
Plasma therapy could get around that issue as the factors are in the blood naturally and I imagine they should pass through the BBB to rejuvenate the Hypothalamus rather than using manufactured small molecules that may be too large to pass through? Though the experiment mentioned in the initial post focused on a small slice of aging function it does show that intervention is possible which is hopeful.
Parabiosis and plasma exchange experiments in the past have certainly hinted at this level of rejuvenation. In 2002 Rando et al showed the Liver regenerated in mice after only 5 weeks of exposure to younger blood so clearly there is some restoration to that part of the Endocrine system. I have also read about a Thymus being regenerated to youthful function via factors too, so this shows at least some of the system does rejuvenate when exposed to younger factors.
There are indications of improved cognitive ability too which indicates factors can penetrate the BBB to rejuvenate the brain.
Harold Katcher published an interesting article about the power of blood factors and is why I believe they hold the key to Epigenetic reprogramming of the aging system.
I share Dr Katcher’s belief that circulating factors could effect the endocrine system and effectively reprogram it by changing the methylation patterns so the glands begin to secrete more youthful factors. I think with sufficient exposure to a younger milleau we may see the system reset to a younger phenotype. The Hypothalamus, spleen, Thyroid, thymus, liver etc… all part of the Endocrine system could after enough exposure stabilize the system and remember how to be young again.
However I am not a Scientist though I do wonder what causes the whole system to destabilize in the first place and I still suspect Telomeres play a part. I would be interested in seeing if circulating factors in any way change telomere length but I guess we wont know until we test it.
From: Sheldon Ball To: steve hill ; Gerontology Research Group Sent: Tuesday, 24 March 2015, 16:35Subject: Re: [GRG] Discovery can help stop emergence of age-related neurodegenerative diseases
The combination of a focus on the central nervous system, especially the hypothalamus and circulating plasma factors seems a more promising approach than telomere length in myoblasts in the study of human aging. I look forward to hearing more of your thoughts on this approach.
At least one of the problems may be that the hypothalamus is hard to get to (in a living person). This should not alter your reasoning process.
On Tue, Mar 24, 2015 at 3:48 AM, steve hill wrote:
Fascinating and further evidence for intervention via Epigenetic reprogramming of the system.
Paraboisis has hinted at this with rejuvenation of cognitive function in mice, could circulating youthful blood factors possibly restore some level of youthful function to the hypothalamus and its endocrines?
Surely if the Hypothalamus is the central controller of aging/metabolism would it not make the ideal target for intervention?
From: “Steven Charlap, MD” To: Gerontology Research Group Sent: Tuesday, 24 March 2015, 3:15Subject: [GRG] Discovery can help stop emergence of age-related neurodegenerative diseases