Part 1 of 2 – DNA Methylation Is Associated With Disease and Aging

DNA methylation is very important in aging solutions.

DNA methylation is becoming recognized as a being associated with specific diseases, and also resulting in age related decline.

Its measurement is used as an important aging biomarker.

DNA methylation step-by-step — starting with the basics so non-scientists, and scientists working in different disciplines, can better understand this:

  • DNA consists of sequences of the molecules adenine, cytosine, guanine, thymine (represented as A, C, G, and T)
  • CpG sites are DNA segments consisting of cytosine, followed by guanine. The “p” means “followed by”.
  • So CpG = “C followed by G”.
  • A methyl group is a specific type of molecule. Things like diet and toxins affect the creation of methyl groups.
  • Methylation is when a methyl group becomes added to a CpG site
  • Methylation typically acts to repress (turn off) gene transcription, although it can trigger transcription and have other effects
  • It does this without changing the DNA sequence
  • Some CpG sites should be methylated for good health, and human development is partly controlled by changing methylation over time.
  • Methyl groups attached to a combination of specific CpG sites is called a methylation pattern.
  • There is a DNA methylation pattern associated with youth.
  • As we grow older, more CpG sites become methylated, so more genes are repressed (or there are other effects to DNA sequence) resulting in the negative effects of aging.
  • Measuring the epigenetic clock is measuring methylation patterns to arrive at an individual’s biological age.
  • Methylation at specific CpG sites are associated with specific diseases. So it’s a small step to see how methylation at specific sites can be associated with the effects, infirmaries and decline of aging – some or all of the following:
    • Reduced strength, energy, and passion for life
    • Faded appearance, aching bones, loss of productivity, decreased sex drive, declining memory, thinning grey hair, sagging skin
    • Just plain feeling bad
    • etc
  • Research is underway to understand the molecular pathways of different therapies resulting in resetting the epigenetic clock to a more youthful pattern.

Next I’ll send more references, including references about the association of methylation with specific components and therapies — rapamycin, senolytics, telomeres etc.

And will try to get some specific CpG sites associated with specific diseases and the effects of aging.



About Johnny Adams

My full-time commitment is to slow and ultimately reverse biological aging and age related decline for more years of healthy living. I’ve been active in this area since the 1970s, steadily building skills and accomplishments. I have a good basic understanding of the science of aging, and have many skills that complement those of scientists so they can focus on science to advance our shared mission. Broad experience Top skills: administration, management, information technology (data and programming), communications, writing, marketing, market research and analysis, public speaking, forging ethical win-win outcomes among stakeholders (i.e. high level "selling"). Knowledge in grant writing, fundraising, finance. Like most skilled professionals, I’m best described as a guy who defines an end point, then figures out how to get there. I enjoy the conception, design, execution and successful completion of a grand plan. Executive Director Gerontology Research Group (GRG). Manages Email discussion forum, web site, meetings and oversees supercentenarian (oldest humans, 110+ years) research. CEO / Executive Director Aging Intervention Foundation (dba for Carl I. Bourhenne Medical Research Foundation), an IRS approved 501(c)(3) nonprofit. Early contributor to Supercentenarian Research Foundation. Co-Founder Geroscience Healthspan Forum. Active contributor to numerous initiatives to increase healthy years of life. Co-authored book on conventional, practical methods available today to slow the processes of aging – nutrition, exercise, behavior modification and motivation, stress reduction, proper supplementation, damage caused by improper programs, risk reduction and others. Fundamental understanding of, and experience in the genomics of longevity (internship analyzing and curating longevity gene papers). Biological and technical includes information technology, software development and computer programming, bioinformatics and protein informatics, online education, training programs, regulatory, clinical trials software, medical devices (CAT scanners and related), hospital electrical equipment testing program. Interpersonal skills – good communication, honest, well liked, works well in teams or alone. Real world experience collaborating in interdisciplinary teams in fast paced organizations. Uses technology to advance our shared mission. Education: MBA 1985 University of Southern California -- Deans List, Albert Quon Community Service Award (for volunteering with the American Longevity Association and helping an elderly lady every other week), George S. May Scholarship, CA State Fellowship. BA psychology, psychobiology emphasis 1983 California State University Fullerton Physiological courses as well as core courses (developmental, abnormal etc). UCLA Psychobiology 1978, one brief but fast moving and fulfilling quarter. Main interest was the electrochemical basis of consciousness. Also seminars at the NeuroPsychiatric Institute. Other: Ongoing conferences, meetings and continuing education. Aging, computer software and information technology. Some molecular biology, biotech, bio and protein informatics, computer aided drug design, clinical medical devices, electronics, HIPAA, fundraising through the Assoc. of Fundraising Professionals. Previous careers include: Marketing Increasing skill set and successes in virtually all phases, with valuable experience in locating people and companies with the greatest need and interest in a product or service, and sitting across the table with decision makers and working out agreements favorable to all. Information Technology: Management, data analysis and programming in commercial and clinical trials systems, and bioinformatics and protein informatics. As IT Director at Newport Beach, CA based technology organization Success Family of Continuing Education Companies, provided online software solutions for insurance and financial professionals in small to Fortune 500 size companies. We were successful with lean team organization (the slower moving competition was unable to create similar software systems). Medical devices: At Omnimedical in Paramount CA developed and managed quality assurance dept. and training depts. for engineers, physicians and technicians. Designed hospital equipment testing program for hospital services division. In my early 20’s I was a musician, and studied psychology and music. Interned with the intention of becoming a music therapist. These experiences helped develop valuable skills used today to advance our shared mission of creating aging solutions.
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